Medical Chemistry
Graduate School of Medical Science
Kyoto Prefectural University of Medicine
Satoshi Uchida M.D., Ph.D.
Appointment
Associate Professor
Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
E-mail:
Web of Science ResearcherID: H-6112-2018; Researchmap; Google Scholar
Education
| 2013 | Ph.D. (Medicine) Internal Medicine, Graduate School of Medicine, The University of Tokyo |
| 2007 | M.D. School of Medicine, The University of Tokyo |
Positions and Employments
| 2020-present | Associate Professor, Graduate School of Medical Science, Kyoto Prefectural University of Medicine |
| 2020-present | Deputy Principal Research Scientist, Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion |
| 2016-2020 | Assistant Professor, Graduate School of Engineering, The University of Tokyo |
| 2013-2016 | Assistant Professor, Graduate School of Medicine, The University of Tokyo |
| 2013 | Project Researcher, Graduate School of Medicine, The University of Tokyo |
| 2007-2009 | Resident, Japan Red Cross Kitami Hospital |
Awards
| 2020 | Young Investigator Award, the Nucleic Acids Therapeutics Society of Japan |
| 2020 | 1st Abstract Prize, 8th International mRNA Health Conference |
| 2018 | 10th Young Scientist Award, the Japan Society of Drug Delivery System |
| 2016 | Japanese and Korean Biomaterials Societies Young Scientist Exchange Program Award |
| 2014 | Young Investigator Award at the Antisense, Gene, Delivery Symposium 2014 |
| 2014 | Outstanding Poster Presentation Award at the American Society of Gene and Cell Therapy (ASGCT) 17th Annual Meeting |
| 2012 | Best Poster Award at Symposium 2012 of the Japanese Society for Biomaterials |
| 2012 | Best Presentation Award at the 28th Japan DDS Conference |
Journals
- Guest editor of Pharmaceutics "Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies"
- Guest editor of Micromachines "Micro/Nano Devices in Biological Medicine"
Research Overview
Accomplishments
Original Papers
- Naoto Yoshinaga, Satoshi Uchida*, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, and Kazunori Kataoka*
Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelles for efficient mRNA delivery
Advanced Healthcare Materials, accepted
DOI: 10.1002/adhm.202102016 - Junjie Li, Zhishen Ge*, Kazuko Toh, Xueying Liu, Anjaneyulu Dirisala, Wendong Ke, Panyue Wen, Hang Zhou, Zheng Wang, Shiyan Xiao, Joachim F. R. Van Guyse, Theofilus A. Tockary, Jinbing Xie, Daniel Gonzalez-Carter, Hiroaki Kinoh, Satoshi Uchida, Yasutaka Anraku, Kazunori Kataoka*
Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer.
Advanced Materials, 2105254 (2021)
DOI: 10.1002/adma.202105254 - Rimpei Kamegawa, Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, Beob Soo Kim, Kanjiro Miyata*
Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery.
ACS Applied Bio Materials, in press
DOI: 10.1021/acsabm.1c00704 - Satoshi Uchida*, Yuto Yamaberi, Masakazu Tanaka, Makoto Oba*
A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA.
Nanoscale, (2021)in press
DOI: 10.1039/D1NR03600A - Eger Boonstra, Hiroaki Hatano, Yuji Miyahara, Satoshi Uchida*, Tatsuro Goda*, Horacio Cabral*
A proton/macromolecule-sensing approach distinguishes changes in biological membrane permeability during polymer/lipid-based nucleic acid delivery
Journal of Materials Chemistry B 9, 4298-4302 (2021)
DOI: 10.1039/D1TB00645B - Naoto Yoshinaga, Mitsuru Naito, Yoshihiro Tachihara, Eger Boonstra, Kensuke Osada, Horacio Cabral*, Satoshi Uchida*
PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials
Pharmaceutics 13, 800 (2021)
DOI: 10.3390/pharmaceutics13060800 - Saed Abbasi, Satoshi Uchida*, Kazuko Toh, Theofilus A. Tockary, Anjaneyulu Dirisala, Kotaro Hayashi, Shigeto Fukushima, Kazunori Kataoka*
Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain.
Journal of Controlled Release 332, 260–268 (2021)
DOI: 10.1016/j.jconrel.2021.02.026 - Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka*
Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle
Biomaterials 270 120681 (2021)
DOI: 10.1016/j.biomaterials.2021.120681 - Naoto Yoshinaga, Satoshi Uchida*, Anjaneyulu Dirisala, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka*
mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency
Journal of Controlled Release 330 317-328 (2021)
DOI: 10.1016/j.jconrel.2020.12.033 - Takuya Miyazaki, Satoshi Uchida, Hiroaki Hatano, Yuji Miyahara, Akira Matsumoto, Horacio Cabral*
Guanidine-phosphate interactions stabilize polyion complex micelles based on flexible catiomers to improve mRNA delivery
European Polymer Journal 140 110028 (2020)
DOI: 10.1016/j.eurpolymj.2020.110028 - Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Takuya Miyazaki, Kazunori Kataoka, Kensuke Osada, Horacio Cabral*, Satoshi Uchida*
Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo
Biomaterials 261 120332 (2020)
DOI: 10.1016/j.biomaterials.2020.120332 - Takuya Miyazaki, Satoshi Uchida, Satoru Nagatoishi, Kyoko Koji, Taehun Hong, Shigeto Fukushima, Kouhei Tsumoto, Kazuhiko Ishihara, Kazunori Kataoka, Horacio Cabral*
Polymeric nanocarriers with controlled chain flexibility boost mRNA delivery in vivo through enhanced structural fastening
Advanced Healthcare Materials 9(16) e2000538 (2020)
DOI: 10.1002/adhm.202000538
Selected as an inside back cover - Anjaneyulu Dirisala, Satoshi Uchida* (co-first), Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka*
Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines
Science Advances 6(26) eabb8133 (2020)
DOI: 10.1126/sciadv.abb8133 - Satoshi Uchida*, Kayoko Yanagihara, Akitsugu Matsui, Kazunori Kataoka, Keiji Itaka*
mRNA as a tool for gene transfection in 3D cell culture for future regenerative therapy
Micromachines 11(4) 426 (2020)
DOI: 10.3390/mi11040426 - Ryosuke Ueki*, Satoshi Uchida (co-first), Naoto Kanda, Naoki Yamada, Ayaka Ueki, Momoko Akiyama, Kazuko Toh, Horacio Cabral, Shinsuke Sando*
A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application
Science Advances 6(14) eaay2801 (2020)
DOI: 10.1126/sciadv.aay2801 - Beob Soo Kim, Shigehito Osawa, Mitsuru Naito, Satomi Ogura, Rimpei Kamegawa, Hiroki Ishida, Hyun Jin Kim, Satoshi Uchida, Kanjiro Miyata*
A 50-nm-sized micellar assembly of thermoresponsive polymer-antisense oligonucleotide conjugates for enhanced gene knockdown in lung cancer by intratracheal administration
Advanced Therapeutics 3(2) 1900123 (2020)
DOI: 10.1002/adtp.201900123 - Mitsuru Naito, Yuta Otsu, Rimpei Kamegawa, Kotaro Hayashi, Satoshi Uchida, Hyun Jin Kim, Kanjiro Miyata*
Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency
Science and Technology of Advanced Materials 20(1) 105-115 (2019)
DOI: 10.1080/14686996.2019.1569818 - Theofilus A. Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada*, Kazunori Kataoka*
Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer
ACS Nano 13(11) 12732-12742 (2019)
DOI: 10.1021/acsnano.9b04676 - Samuel T. Crowley, Yuta Fukushima, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka*
Enhancement of motor function recovery after spinal cord injury in mice by delivery of brain-derived neurotrophic factor mRNA
Molecular Therapy - Nucleic Acids 17 465-476 (2019)
DOI: 10.1016/j.omtn.2019.06.016 - Naoto Yoshinaga, Eol Cho, Kyoko Koji, Yuki Mochida, Mitsuru Naito, Kensuke Osada, Kazunori Kataoka, Horacio Cabral*, Satoshi Uchida*
Bundling mRNA strands to prepare nano-assemblies with enhanced stability towards RNase for in vivo delivery
Angewandte Chemie International Edition 58(33) 11360-11363 (2019)
DOI: 10.1002/anie.201905203 - Anjaneyulu Dirisala, Satoshi Uchida*, Theofilus A. Tockary, Naoto Yoshinaga, Junjie Li, Shigehito Osawa, Lahari Gorantla, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka*
Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability
Journal of Drug Targeting 27(5-6) 670-680 (2019)
DOI: 10.1080/1061186x.2018.1550646 - Chin-Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itaka*
Treatment of intervertebral disk disease by the administration of mRNA encoding a cartilage-anabolic transcription factor
Molecular Therapy - Nucleic Acids 16 162-171 (2019)
DOI: 10.1016/j.omtn.2019.02.012 - Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y Tanaka, Mitsunobu R Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata*, Kazunori Kataoka*
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Nature Communications 10(1) 1894 (2019)
DOI: 10.1038/s41467-019-09856-w - Shota Kurimoto, Naoto Yoshinaga, Kazunori Igarashi, Yu Matsumoto, Horacio Cabral*, Satoshi Uchida*
PEG-OligoRNA hybridization of mRNA for developing sterically stable lipid nanoparticles toward in vivo administration
Molecules 24(7) 1303 (2019)
DOI: 10.3390/molecules24071303 - Naoto Yoshinaga, Satoshi Uchida* (co-first), Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka*
Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection
Biomaterials 197 255-267 (2019)
DOI: 10.1016/j.biomaterials.2019.01.023 - Akitsugu Matsui, Satoshi Uchida* (co-first), Akimasa Hayashi, Kazunori Kataoka, Keiji Itaka*
Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection
Journal of Controlled Release 285 1-11 (2018)
DOI: 10.1016/j.jconrel.2018.06.033 - Kayoko Yanagihara, Satoshi Uchida, Shinsuke Ohba, Kazunori Kataoka, Keiji Itaka*
Treatment of bone defects by transplantation of genetically modified mesenchymal stem cell spheroids
Molecular Therapy - Methods & Clinical Development 9 358-366 (2018)
DOI: 10.1016/j.omtm.2018.04.006 - Satoshi Uchida*, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka*
Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination
Biomaterials 150 162-170 (2018)
DOI: 10.1016/j.biomaterials.2017.09.033 - Naoto Yoshinaga, Takehiko Ishii, Mitsuru Naito, Taisuke Endo, Satoshi Uchida, Horacio Cabral, Kensuke Osada*, Kazunori Kataoka*
Polyplex micelles with phenylboronate/gluconamide cross-linking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP concentration
Journal of the American Chemical Society 139(51) 18567-18575 (2017)
DOI: 10.1021/jacs.7b08816 - Yasutaka Anraku, Hiroya Kuwahara,Yu Fukusato, Akihiro Mizoguchi, Takehiko Ishii, Keiko Nitta, Yu Matsumoto, Kazuko Toh, Kanjiro Miyata, Satoshi Uchida, Kazutaka Nishina, Kensuke Osada, Keiji Itaka, Nobuhiro Nishiyama, Hidehiro Mizusawa, Tatsuya Yamasoba, Takanori Yokota*, Kazunori Kataoka*
Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
Nature Communications 8 1001 (2017)
DOI: 10.1038/s41467-017-00952-3 - Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kärt Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O. Rädler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka*, Ernst Wagner*
Systemic delivery of folate-PEG siRNA lipopolyplexes with enhanced intracellular stability for in vivo gene silencing in leukemia
Bioconjugate Chemistry 28(9) 2393-2409 (2017)
DOI: 10.1021/acs.bioconjchem.7b00383 - Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka*
Improved brain expression of anti-amyloid beta scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer
Current Alzheimer Research 14(3) 295-302 (2017)
DOI: 10.2174/1567205013666161108110031 - Qixian Chen, Kensuke Osada*, Zhishen Ge, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Akitsugu Matsui, Kazuko Toh, Kaori M. Takeda, Xueying Liu, Takahiro Nomoto, Tekihiko Ishii, Makoto Oba, Yu Matsumoto, Kazunori Kataoka*
Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting
Biomaterials 113 253-265 (2017)
DOI: 10.1016/j.biomaterials.2016.10.042 - Satoshi Uchida, Kentaro Hayakawa, Toru Ogata, Sakae Tanaka, Kazunori Kataoka*, Keiji Itaka*
Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids
Biomaterials 109 1-11 (2016)
DOI: 10.1016/j.biomaterials.2016.09.007 - Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka*, Keiji Itaka*
Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles
Journal of Controlled Release 235 268-275 (2016)
DOI: 10.1016/j.jconrel.2016.06.001 - Hailati Aini, Keiji Itaka*, Ayano Fujisawa, Hirokuni Uchida, Satoshi Uchida, Shigeto Fukushima, Kazunori Kataoka, Taku Saito, Ung-il Chung, Shinsuke Ohba*
Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment
Scientific Reports 6 18743 (2016)
DOI: 10.1038/srep18743 - Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary, Kaori Machitani Takeda, Hirokuni Uchida, Kensuke Osada, Keiji Itaka*, Kazunori Kataoka*
Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety
Biomaterials 82 221-228 (2016)
DOI: 10.1016/j.biomaterials.2015.12.031 - Hirokuni Uchida, Keiji Itaka, Satoshi Uchida, Takehiko Ishii, Tomoya Suma, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka*
Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure
Journal of the American Chemical Society 138(5) 1478-1481 (2016)
DOI: 10.1021/jacs.5b11726 - Akitsugu Matsui, Satoshi Uchida (co-first), Takehiko Ishii, Keiji Itaka*,Kazunori Kataoka*
Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases
Scientific Reports 5 15810 (2015)
DOI: 10.1038/srep15810 - Yanmin Li, Kensuke Osada*, Qixian Chen, Theofilus A. Tockary, Anjaneyulu Dirisala, Kaori M. Takeda, Satoshi Uchida, Kazuya Nagata, Keiji Itaka, Kazunori Kataoka*
Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression
Biomacromolecules 16(9) 2664-2671 (2015)
DOI: 10.1021/acs.biomac.5b00491 - Tomoyuki Okuda, Yumiko Suzuki, Yuko Kobayashi, Takehiko Ishii, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Hirokazu Okamto*
Development of biodegradable polycation-based inhalable dry gene powders by spray freeze drying
Pharmaceutics 7(3) 233-254 (2015)
DOI: 10.3390/pharmaceutics7030233 - Keiji Itaka*, Satoshi Uchida, Akitsugu Matsui, Kayoko Yanagihara, Masaru Ikegami, Taisuke Endo, Takehiko Ishii, Kazunori Kataoka
Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation
Journal of Visualized Experiments 101 e52384 (2015)
DOI: 10.3791/52384 - Satoshi Uchida, Kazunori Kataoka*, Keiji Itaka*
Screening of mRNA chemical modification to maximize protein expression with reduced immunogenicity
Pharmaceutics 7(3) 137-151 (2015)
DOI: 10.3390/pharmaceutics7030137 - Kentaro Hayakawa, Satoshi Uchida, Toru Ogata, Sakae Tanaka, Kazunori Kataoka*, Keiji Itaka*
Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury
Journal of Controlled Release 197 1-9 (2015)
DOI: 10.1016/j.jconrel.2014.10.027 - Qixian Chen, Kensuke Osada*, Matthew Pennisi, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Yanmin Li, Kaori M. Takeda, Satoshi Oniyanagi, Keiji Itaka, Kazunori Kataoka*
A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle
Soft Matter 11(14) 2718-2722 (2015)
DOI: 10.1039/c4sm02850c - Anjaneyulu Dirisala, Kensuke Osada*, Qixian Chen, Theofilus A. Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka*
Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors
Biomaterials 35(20) 5359-5368 (2014)
DOI: 10.1016/j.biomaterials.2014.03.037 - Kazuya Nagata, Keiji Itaka*, Miyuki Baba, Satoshi Uchida, Takehiko Ishii, Kazunori Kataoka*
Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury
Journal of Controlled Release 183 27-34 (2014)
DOI: 10.1016/j.jconrel.2014.03.021 - Satoshi Uchida, Keiji Itaka*, Takahiro Nomoto, Taisuke Endo, Yu Matsumoto, Takehiko Ishii, Kazunori Kataoka*
An injectable spheroid system with genetic modification for cell transplantation therapy
Biomaterials 35(8) 2499-2506 (2014)
DOI: 10.1016/j.biomaterials.2013.12.012 - Zhishen Ge, Qixian Chen, Kensuke Osada*, Xueying Liu, Theofilus A. Tockary, Satoshi Uchida, Anjaneyulu Dirisala, Takehiko Ishii, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Makoto Oba, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka*
Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors
Biomaterials 35(10) 3416-3426 (2014)
DOI: 10.1016/j.biomaterials.2013.12.086 - Theofilus A. Tockary, Kensuke Osada*, Qixian Chen, Kaori Machitani, Anjaneyulu Dirisala, Satoshi Uchida, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Keiji Itaka, Koji Nitta, Kuniaki Nagayama, Kazunori Kataoka*
Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers
Macromolecules 46(16) 6585-6592 (2013)
DOI: 10.1021/ma401093z - Hiroyasu Takemoto, Kanjiro Miyata*, Shota Hattori, Takehiko Ishii, Tomoya Suma, Satoshi Uchida, Nobuhiro Nishiyama, Kazunori Kataoka*
Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response
Angewandte Chemie International Edition 52(24) 6218-6221 (2013)
DOI: 10.1002/anie.201300178 - Satoshi Uchida, Keiji Itaka*, Hirokuni Uchida, Kentaro Hayakawa, Toru Ogata, Takehiko Ishii, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka*
In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle
PLoS ONE 8(2) e56220 (2013)
DOI: 10.1371/journal.pone.0056220 - Taisuke Endo, Keiji Itaka*, Momoko Shioyama, Satoshi Uchida, Kazunori Kataoka*
Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation
Drug Delivery and Translational Research 2(5) 398-405 (2012)
DOI: 10.1007/s13346-012-0091-1 - Satoshi Uchida, Keiji Itaka*, Qixian Chen, Kensuke Osada, Takehiko Ishii, Masa-Aki Shibata, Mariko Harada-Shiba, Kazunori Kataoka*
PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses
Molecular Therapy 20(6) 1196-1203 (2012)
DOI: 10.1038/mt.2012.20 - Qixian Chen, Kensuke Osada*, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A. Tockary, Taisuke Endo, Zhishen Ge, Hiroaki Kinoh, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka*
Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors
Biomaterials 33(18) 4722-4730 (2012)
DOI: 10.1016/j.biomaterials.2012.03.017 - Tomoya Suma, Kanjiro Miyata, Takehiko Ishii, Satoshi Uchida, Hirokuni Uchida, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka*
Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain
Biomaterials 33(9) 2770-2779 (2012)
DOI: 10.1016/j.biomaterials.2011.12.022 - Satoshi Uchida, Keiji Itaka*, Qixian Chen, Kensuke Osada, Kanjiro Miyata, Takehiko Ishii, Mariko Harada-Shiba, Kazunori Kataoka*
Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity
Journal of Controlled Release 155(2) 296-302 (2011)
DOI: 10.1016/j.jconrel.2011.04.026 - Tomoyuki Yoshida, Satoshi Uchida, Masayoshi Mishina*
Regulation of synaptic vesicle accumulation and axon terminal remodeling during synapse formation by distinct Ca2+signaling
Journal of Neurochemistry 111(1) 160-170 (2009)
DOI: 10.1111/j.1471-4159.2009.06309.x
Reviews
- Saed Abbasi*, Satoshi Uchida*
Multifunctional immunoadjuvants for use in minimalist nucleic acid vaccines
Pharmaceutics 13 644 (2021)
DOI: doi:10.3390/pharmaceutics13050644 - Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral*
Nanomedicine-based approaches for mRNA delivery
Molecular Pharmaceutics 17(10) 3654-3684 (2020)
DOI: 10.1021/acs.molpharmaceut.0c00618
Selected as a cover page - Satoshi Uchida*, Kazunori Kataoka*
Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA
Journal of Biomedical Materials Research Part A 107(5) 978-990 (2019)
DOI: 10.1002/jbm.a.36614
Proceedings
- Satoshi Uchida*, Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Horacio Cabral
mRNA Structuring for Stabilizing mRNA Nanocarriers and Improving Their Delivery Efficiency
Materials Proceedings, 4 82 2021 - Satoshi Uchida, Kyoko Koji, Naoto Yoshinaga, Horacio Cabral
Assembling several mRNA strands for facilitating mRNA delivery with and without using carriers
Molecular Therapy, 29 (4, S1) 55 (2021) - Eger Boonstra, Hiroaki Hatano, Tatsuro Goda, Satoshi Uchida, Horacio Cabral, Yuji Miyahara
Mechanistic Analyses of Polymer/Lipid-Based Gene Transfection Processes through Membrane Integrity Assay Using Proton Sensing Transistor
Materials Proceedings, 4 53 2021
DOI: 10.3390/IOCN2020-07988 - Takuya Miyazaki, Satoshi Uchida, Yuji Miyahara, Akira Matsumoto, Horacio Cabral
Development of Flexible Polycation-Based mRNA Delivery Systems for In Vivo Applications
Materials Proceedings, 4 5 2021
DOI: 10.3390/IOCN2020-07857 - Naoto Yoshinaga, Mitsuru Naito, Satoshi Uchida, Horacio Cabral, Kensuke Osada, Kazunori Kataoka
Design of polyplex micelles with phenylboronate ester cross-linking in the core exerting promoted gene transfection through responsivity to intracellular pH and ATP concentration
Abstracts of Papers of the American Chemical Society 256 757 (2018) - Satoshi Uchida, Keiji Itaka, Kazunori Kataoka
Incorporation of immunostimulatory property to messenger RNA molecule by hybridizing RNA to poly A sequence for effective vaccination
Molecular Therapy 26 s243-244 (2018) - Samuel T. Crowley, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka
Nonviral Delivery of BDNF mRNA Polyplex Improves Recovery After Spinal Cord Injury in Mice
Molecular Therapy 25 s317 (2017) - Yuta Fukushima, Hideaki Imai, Satoshi Uchida, Keiji Itaka, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito
Transient BDNF introduction therapy against delayed neuronal death in hippocampal CA1 neurons using biocompatible nanomicellar mRNA carrier
Journal of Cerebral Blood Flow and Metabolism 37 201 (2017) - Akitsugu Matsui, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka
Anti-apoptotic treatment by in vivo mRNA administration using polyplex nanomicelle
Human Gene Therapy 27 A184 (2016) - Kayoko Yanagihara, Satoshi Uchida, Fumiko Yano, Kazunori Kataoka, Nobuhiko Haga, Keiji Itaka
Gene therapy for achondroplasia by continuously regulating FGFR3 signal
Human Gene Therapy 27 A149 (2016) - Keiji Itaka, Hailati Aini, Satoshi Uchida, Shinsuke Ohba, Ung-il Chung, Kazunori Kataoka A
disease-modifying strategy for osteoarthritis treatment by intraarticular injection of mRNA encoding cartilage- anabolic transcription factor
Human Gene Therapy 27 A148 (2016) - Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus A. Tockary, Kaori M. Takeda, Hirokuni Uchida, Kensuke Osada, Keiji Itaka, Kazunori Kataoka
Anti-Angiogenic Therapy for Pancreatic Cancer by Systemic Delivery of Messenger RNA Using Polyplex Nano Micelle
Molecular Therapy 24 s234-235 (2016) - Satoshi Uchida, Akitsugu Matsui, Kazunori Kataoka, Keiji Itaka
Messenger RNA-based therapy for an apoptosis-related disease in the liver
Human Gene Therapy 26 A77-78 (2015) - Chin-Yu Lin, Satoshi Uchida, Masaru Ikegami, Keiji Itaka, Kazunori Kataoka
Polyplex namomicelles assembled with neprilysin mRNA augmented clearance of beta-amyloid peptide from intracerebroventricular infusion
Human Gene Therapy 26 A21 (2015) - Satoshi Uchida, Akitsugu Matsui, Keiji Itaka, Kazunori Kataoka
Messenger RNA (mRNA)-Based Gene Therapy for Introducing Anti-Apoptotic Factor
Molecular Therapy 23 s195 (2015) - Kayoko Yanagihara, Satoshi Uchida, Masaru Ikegami, Yujiro Meada, Shinsuke Oba, Ung-il Chung, Kazunori Kataoka, Keiji Itaka
Treating bone defect by transplantation of genetically modified MSC spheroids
Human Gene Therapy 25 A69-70 (2014) - Keiji Itaka, Miyuki Baba, Satoshi Uchida, Kazunori Kataoka
In vivo mRNA introduction using polyplex nanomicelles to treat neurological disorders
Human Gene Therapy 25 A36 (2014) - Satoshi Uchida, Keiji Itaka, Kentaro Hayakawa, Toru Ogata, Kazunori Kataoka
Treatment of Spinal Cord Injury by Transplantation of BDNF-Transfected Mesenchymal Stem Cell Spheroids
Molecular Therapy 22 s183-184 (2014) - Masaru Ikegami, Satoshi Uchida, Hirokuni Uchida, Kazuya Nagata, Kazunori Kataoka, Keiji Itaka
Enhanced Transfection of mRNA Transcribed From Elongated-poly(A/T) Tail- Containing Vector
Molecular Therapy 22 s43 (2014) - Keiji Itaka, Satoshi Uchida, Kazunori Kataoka
In vivo mRNA introduction to central nervous system using polyplex nanomicelles
Human Gene Therapy 23 A59 (2012) - Satoshi Uchida, Kentaro Hayakawa, Toru Ogata, Kazunori Kataoka, Keiji Itaka
In Vivo mRNA Delivery to Central Nervous System Using Polyplex Nanomicelles
Molecular Therapy 20 s154 (2012) - Keiji Itaka, Satoshi Uchida, Qixian Chen, Takehiko Ishii, Kensuke Osada, Kazunori Kataoka
Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses
Human Gene Therapy 22(10) A88 (2011) - Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Takehiko Ishii, Mariko Harada-Shiba, Masa-Aki Shibata, Kazunori Kataoka
Combinatorial Use of Block- and Homo-Polycation To Form DNA Polyplex Enhances Transgene Expressions in Mouse Lung with Minimal Toxicity
Molecular Therapy 19 s24 (2011) - Tomoyuki Yoshida, Akiko Uotsu, Satoshi Uchida, Masayoshi Mishina
Distinct calcium signaling for synaptic vesicle accumulation and morphological remodeling during axon terminal differentiation of zebrafish olfactory sensory neurons
Journal of Pharmacological Sciences 106 113P (2008)
Books
- Satoshi Uchida, Keiji Itaka, Kazunori Kataoka
Drug and gene delivery in the lungs
Nanoparticles in the lung: environmental exposure and drug delivery, Eds., A. Tsuda, P. Gehr, CRC press, Taylor & Francis Group, 2015, 225-238
Invited lectures
- Satoshi Uchida, Development of mRNA nano-vaccines against COVID-19 and future pandemic, 7th COINS Symposium, ~Future Medicine is Comin' to Town~, Online, Dec. 4, 2020
- Satoshi Uchida, mRNA nanomachine for treating rare genetic disorders, India-Japan Webinar on "Rare Genetic Disorders”, organized by Embassy of India, Tokyo, Online, Oct. 16, 2020
- Satoshi Uchida, Development of mRNA polyplex micelles through engineering polymers and mRNA for in vivo therapeutic applications, IBS CNM Seminar, Yonsei University, Seoul, South Korea, Jan. 10, 2020
- Satoshi Uchida, Nanoengineering mRNA through short RNA hybridization for biomedical application, 1st Thailand-Australia-Japan Joint Research Meeting on Nanomedicine, Bangkok, Thailand, Oct. 29, 2019
- Satoshi Uchida, Messenger RNA designing through short RNA oligonucleotide hybridization, cfaed Seminar Series, Technische Universität Dresden, Dresden, Germany, Nov. 14, 2018
- Satoshi Uchida, Yuta Fukushima, Chin-Yu Lin, Keiji Itaka, Kazunori Kataoka, Development of messenger RNA-loaded polyplex nanomicelle for the treatment of central nervous system diseases. 20th Anniversary International Symposium of the Korea Society for Biomaterials 2016, Seoul, Korea, Sep. 29, 2016