Medical Chemistry
Graduate School of Medical Science
Kyoto Prefectural University of Medicine
Hidetomo YOKOO
Appointment
Assistant Professor
Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
E-mail:
Education
| 2014 | B.S., Department of Chemistry, Faculty of Science, Saitama University |
| 2016 | M.S., Graduate School of Mdical and Dental Sciencies, Tokyo Medical and Dental University |
| 2019 | Ph.D., Graduate School of Mdical and Dental Sciencies, Tokyo Medical and Dental University |
Positions and Employments
| 2019-2020 | Postdoctoral Fellow, Division of Organic Chemistry, National Institute of Health Sciences |
| 2019-2020 | Visiting Researcher, Yokohama City University Graduate School of Medical Life Science |
| 2019 | Postdoctoral Fellow, Division of Chemistry, The Scripps Research Institute |
| 2020-2021 | Researcher, Division of Organic Chemistry, National Institute of Health Sciences |
| 2021-present | Assistant Professor, Graduate School of Medical Science, Kyoto Prefectural University of Medicine |
| 2021-present | Visiting Researcher, Division of Organic Chemistry, National Institute of Health Sciences |
Awards
| 2022 | Seiren award |
| 2021 | ENT M Dr. Asano Noboru & Teruko Fund Medical Basic Research Grant |
| 2018 | 3rd International Symposium on Biomedical Engineering Young Researchers Poster Award |
| 2018 | Student presentation award at 138th annual meeting of the pharmaceutical society of Japan |
Accomplishments
Original Papers
- Hidetomo Yokoo, Norihito Shibata*, Yusuke Demizu*,
In silico design, synthesis and evaluation of PROTAC against hematopoietic prostaglandin D synthase
Methods Mol. Biol. accepted. - Hidetomo Yokoo#, Seiji Tanaka#, Eiichi Yamamoto, Genichiro Tsuji, Yosuke Demizu*, Nahoko Uchiyama*,
Advanced solid-state NMR analysis of two crystal forms of ranitidine hydrochloride: Detection of 1H-14N intra-/intermolecular correlations.
Chem. Pharm. Bull. In press - Yuki Murakami#, Hinata Osawa#, Takashi Kurohara#, Yuta Yanase, Takahito Ito,Hidetomo Yokoo, Norihito. Shibata, Mikihiko Naito, Kosuke Aritake, Yosuke Demizu*,
Structure–Activity Relationship Study of PROTACs against Hematopoietic Prostaglandin D2 Synthase.
RSC Med. Chem. Advance Article (2022)
DOI:10.1039/D2MD00284A - Hidetomo Yokoo#, Takashi Misawa#, Takuma Kato, Masakazu Tanaka, Yosuke Demizu*, Makoto Oba*,
Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine.
Bioorg. Med. Chem. In press.
DOI:10.1016/j.bmc.2022.116997 - Hanqiao Xu#, Takashi Kurohara#, R. Takano, Hidetomo Yokoo, Norihito Shibata, Nobumichi Ohoka, Takao Inoue, Mikihiko Naito, Yosuke Demizu*,
Development of rapid and facile solid-phase synthesis of PROTACs via a variety of binding styles.
ChemistryOpen 11 e202200131 (2022)
DOI:10.1002/open.202200131 - Michihiko Aoyama*, Minoru Tada, Hidetomo Yokoo, Yosuke Demizu, Akiko Ishii-Watabe,
Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates.
Pharm. Res. 39 89-103 (2022)
DOI:10.1007/s11095-021-03158-x - Takashi Kurohara, Takahito Ito, Genichiro Tsuji*, Takashi Misawa*, Hidetomo Yokoo, Yuta Yanase, Takuji Shoda, Takatoshi Sakai, Junko Hosoe, Nahoko Uchiyama, Hiroshi Akiyama, Yosuke Demizu
Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor.
Bioorg. Med. Chem. 49 116425 (2021)
DOI:10.1016/j.bmc.2021.116425 - Hidetomo Yokoo#, Nobumichi Ohoka#, Mami Takyo, Takahito Ito, Keisuke Tsuchiya, Takashi Kurohara, Kiyoshi Fukuhara, Takao Inoue, Mikihiko Naito, Yosuke Demizu*
Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation.
Int. J. Mol. Sci. 22 8772 (2021)
DOI:10.3390/ijms22168772 - Nobumichi Ohoka#, Hidetomo Yokoo#, Keiichiro Okuhira, Yosuke Demizu, Mikihiko Naito*
Molecular design, synthesis and evaluation of SNIPER(ER) that induces targeted protein degradation of ERα.
Methods Mol. Biol. 2418, 363-382 (2022). - Hidetomo Yokoo*, Motoharu Hirano, Nobumichi Ohoka, Takashi Misawa, Yosuke Demizu*
Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine.
J. Pept. Sci. e3360 (2021).
DOI:10.1002/psc.3360 - Hidetomo Yokoo, Norihito Shibata*, Akinori Endo, Takahito Ito, Yuta Yanase, Yuki Murakami, Kiyonaga Fujii, Yasushi Saeki, Mikihiko Naito*, Kosuke Aritake*, Yosuke Demizu*
Discovery of a highly potent and selective degrader targeting hematopoietic prostaglandin D synthase via in silico design.
J. Med. Chem. 64, 15868-15882 (2021).
Selected as Supplementary Cover.
ChemRxiv DOI: 10.26434/chemrxiv.14739486.v1 - Hidetomo Yokoo, Eiichi Yamamoto*, Sayaka Masada, Nahoko Uchiyama,Genichiro Tsuji, Takashi Hakamatsuka, Yosuke Demizu, Ken-ichi Izutsu, Yukihiro Goda
N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride.
Chem. Pharm. Bull. 69 872-876 (2021). - Yuto Yamaberi, Ryo Eto, Tomohiro Umeno, Takuma Kato, Mitsunobu Doi, Hidetomo Yokoo, Makoto Oba*, Masakazu Tanaka*
Synthesis of (S)-(–)-cucurbitine and conformation of its homopeptides.
Org. Lett. 23 4358-4362 (2021).
Selected as Supplementary Cover.
DOI:10.1021/acs.orglett.1c01291 - Hanqiao Xu, Nobumichi Ohoka, Hidetomo Yokoo, Kanako Nemoto, Takashi Ohtsuki, Hiroshi Matsufuji, Mikihiko Naito, Takao Inoue, Genichiro Tsuji*, Yousuke Demizu*
Development of agonist-based PROTACs targeting liver X receptor.
Front. Chem. 9 674967 (2021) - Yoshinori Tsukumo, Genichiro Tsuji, Hidetomo Yokoo, Norihito Shibata, Nobumichi Ohoka, Yusuke Demizu, Mikihiko Naito*
Protocols for synthesis of SNIPERs and the methods to evaluate the anticancer effects.
Methods Mol. Biol. 2365 331-347 (2021). - Hidetomo Yokoo, Norihito Shibata, Miyako Naganuma, Takahito Ito, Kosuke Aritake,* Mikihiko Naito,* Yosuke Demizu*
Development of hematopoietic prostaglandin D synthase-degradation inducer.
ACS Med. Chem. Lett. 12 236–241 (2021)
Selected as Supplementary Cover.
DOI: 10.1021/acsmedchemlett.0c00605
ChemRxiv DOI:10.26434/chemrxiv.13040723.v1. - Motoharu Hirano, Chihiro Saito, Satoshi Uchida, Chihiro Goto, R. Kawano, Takashi Misawa,* Yosuke Demizu*
Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence.
Molecules 26 444 (2021)
DOI:10.3390/molecules26020444. - R. Terui, Y. Yanase, Hidetomo Yokoo, Yoshitomo Suhara, Makoto Makishima, Yosuke Demizu,* Takashi Misawa*
Development of Selective TGR5 Ligands Based on the 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene Skeleton
ChemMedChem 330 317-328 (2021)
DOI: 10.1002/cmdc.202000567
Selected as Front Cover. - Motoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa,* Yosuke Demizu*
Rational Design of Helix-stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling.
ChemPlusChem 85, 2731-2736 (2020).
DOI:10.1002/cplu.202000749 - Yasuhiro. Abe, Eiichi Yamamoto, Hiroyuki Yoshida, Akiko Usui, Naomi Tomita, Hitomi Kanno, Sayaka Masada, H Yokoo, Genichiro Tsuji, Nahoko Uchiyama, T. Hakamatsuka, Yosuke Demizu, K. Izutsu, Y. Goda, H. Okuda
Temperature-dependent formation of N-nitrosodimethylamine during the storage of ranitidine reagent powders and tablets.
Chem Pram Bull 68 1008-1012 (2020)
DOI:10.1248/cpb.c20-00431 - Hidetomo Yokoo, N. Ohoka, Mikihiko Naito, Yosuke Demizu*
Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.
Bioorg. Med. Chem. 28, 115595 (2020)
DOI: 10.1016/j.bmc.2020.115595 - Genichiro Tsuji, M. Yusaa, Sayaka Masadaa, Hidetomo Yokoo, J. Hosoe, T. Hakamatsuka, Yosuke Demizu, Nahoko Uchiyama*
Facile synthesis of kwakhurin, a marker compound of Pueraria mirifica and its quantitative NMR analysis for standardization as a reagent.
Chem. Pharm. Bull. 68 797-801 (2020).
DOI: 10.1248/cpb.c20-00346 - Miyako Naganuma, Hidetomo Yokoo, Takashi Misawa, Kenji. Matsuno, Genichiro Tsuji*, Yosuke Demizu*
Design and synthesis of 4-(2-pyrrolyl)-4-phenylheptane derivatives as estrogen receptor antagonists.
Heterocycles 101, 429-434 (2020)
DOI: 10.3987/COM-19-14121 - Keisuke Tsuchiya, Tomohiro Umeno, Genichiro Tsuji, Hidetomo Yokoo, Masakazu Tanaka, Kiyoshi Fukuhara, Yosuke Demizu, Takashi Misawa*
Development of photoswitchable estrogen receptor ligands
Chem. Pharm. Bull. 68, 398-402 (2020).
DOI:10.1248/cpb.c19-01108 - Hidetomo Yokoo, Hiroyuki Kagechika, Ayumi Ohsaki, Tomoya Hirano*
A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions.
ChemPlusChem 84 1716-1719 (2019)
DOI:10.1002/cplu.201900489 - Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika, Tomoya Hirano*
Unique properties of 1,5-naphthyridin-2(1H)-one derivatives as environmental-polarity-sensitive fluorescent dyes.
Eur. J. Org. Chem. 5 679-687 (2018)
DOI:10.1002/ejoc.201701609
Selected as Outstanding Organics. (Highlight) - Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika, Tomoya Hirano*
Structural development of canthin-5,6-dione moiety as a fluorescent dye and its application to novel fluorescent sensors.
Tetrahedron 72, 5872-5879 (2016)
DOI: 10.1016/j.tet.2016.08.014
Reviews
- Hidetomo Yokoo*, Miyako Naganuma, Makoto Oba, Yosuke Demizu*,
Recent Advances in PROTAC Technology toward New Therapeutic Modalities.
Chem. Biodivers. e202200828 (2022)
DOI: 10.1002/cbdv.2022008288 - Hidetomo Yokoo, Makoto Oba*, Satoshi Uchida*
Cell-penetrating peptides: emerging tools for mRNA delivery.
Pharmaceutics 14 78 (2022)
DOI: 10.3390/pharmaceutics14010078 - Hidetomo Yokoo, Motoharu Hirano, Takashi Misawa, Yosuke Demizu*
Helical antimicrobial peptide foldamers containing non-proteinogenic amino acids
ChemMedChem 17 3654-3684 (2020)
DOI:10.1002/cmdc.202000940 - Hidetomo Yokoo, Takashi Misawa*, Yosuke Demizu*
De novo Design of Cell-penetrating Foldamers.
Chem. Rec. 20 912-921 (2020)
DOI: 10.1002/tcr.202000047
Selected as Front Cover.
Books
- Tomoya Hirano, Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika
Development of Novel Fluorescent Sensors Based on Fluorescent Natural Compounds.
Biomedical Engineering
Jenny Stanford Publishing, Chapter6 (2021) - Hidetomo Yokoo，Yosuke Demizu
Organic chemistry-based approach for TPD drug
Farumashia 2021 - Hidetomo Yokoo，Yosuke Demizu
Design and synthetic strategies for TPD drug discovery
The CELL Vol.53 No.3, 2021 Targeted Protein Degradation 16-19