医学部医学科　化学教室
大学院医学研究科　医系化学

学歴

2011年3月	長崎県立川棚高等学校卒業
2015年3月	長崎大学薬学部薬科学科卒業
2017年3月	長崎大学大学院医歯薬学総合研究科生命薬科学専攻博士前期課程修了
2020年3月	長崎大学大学院医歯薬学総合研究科生命薬科学専攻博士後期課程修了
同年	博士（薬科学）　取得

研究·職歴

2017年4月〜2020年3月	日本学術振興会 特別研究員 (DC1)
2020年4月〜2023年8月	昭和薬科大学　特任助教
2023年9月〜現在	京都府立医科大学　大学院医学研究科　学内講師

所属学会

• 日本薬学会（2015年〜）
• 日本ペプチド学会（2021年～）

受賞歴

• 2023年度日本薬学会関東支部奨励賞（2023年9月）
  『ドナー・アクセプター型分子の特性を利用した分析試薬の開発』
• 日本分析化学会第71年会　若手ポスター賞（2022年9月）
  『酸塩基反応型アミン検出試薬の開発とペプチド合成への適用』
• 第33回バイオメディカル分析科学シンポジウム　星野賞　研究奨励賞（2021年9月）
  『グアニジノ基を有する蛍光分子によるメタノール選択的蛍光検出法の開発』
• 第35回日本薬学会九州支部大会　学生発表賞（2018年11月）
  『配座自由度を制限したペプチドフォルダマーによる不斉触媒反応の開発』

業績

原著論文（英文）

1. Tomohiro Umeno*, Hiroyasu Takemoto, Makoto Oba*
   Plasmid DNA delivery using arginine-rich cell-penetrating L/D-peptides containing α-aminoisobutyric acids.
   Organic & Biomolecular Chemistry, 23, 5191-5196, 2025.
   
2. Yuma Saimoto, Daiki Kusakabe, Kazushi Morimoto, Yuta Matsuoka, Eisho Kozakura, Nao Kato, Kayoko Tsunematsu, Tomohiro Umeno, Tamiko Kiyotani, Shota Matsumoto, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa, Koji Uchida, Satoru Karasawa, Mirinthorn Jutanom, Ken-ichi Yamada*
   Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization.
   Nature Communications, 16, 3554, 2025.
   
3. Yasufumi Fuchi*, Keita Ikeno, Moeka Fujihara, Tomohiro Umeno, Masatoshi Kawahata, Kazuteru Usui, Satoru Karasawa*
   Synthesis and characterization of emissive 1,9,10-anthyridine derivatives with donor and acceptor groups.
   Journal of Molecular Structure, 1334, 141840, 2025.
   
4. Sachi Ibuki, Tomohiro Umeno, Makoto Oba*, Hiroyasu Takemoto*
   Rearrangement in Diamine-Based Polyzwitterion Side Chains for the Modulated pH Responsiveness Regardless of Their Comparable pKa Values.
   Macromolecular Rapid Communications, in press, 2025.
   
5. Makoto Oba*, Hikaru Nonaka, Tomohiro Umeno, Takuma Kato, Mitsunobu Doi, Atsushi Ueda, Masakazu Tanaka*
   Redox-Responsive Side Chain Structural Changes in a Seven-Membered Cyclic α,α-Disubstituted α-Amino Acid with a Disulfide Bond Enable Reversible Conformational Changes in Peptides.
   ChemPlusChem, 90, e202400772, 2025.
   
6. Tomohiro Umeno*, Mio Tanaka, Moeka Fujihara, Naoko Iizuka, Shota Matsumoto, Kazuteru Usui, Satoru Karasawa*
   Advanced pH Indicators Consisting of BODIPY and Coumarin Fluorophores with a Guanidinyl Structure Capable of Methanol Recognition.
   Asian Journal of Organic Chemistry, 14, e202400605, 2025.
   
7. Naoko Iizuka, Yuika Akizuki, Tomohiro Umeno, Noriko Suzuki, Kazuteru Usui, Daisuke Yoshihara, Tatsuya Naganuma, Satoru Karasawa*
   Nitric Oxide Radical-Based Nanoparticles as Magnetic Resonance Imaging Probes for Ascorbic Acid Quantification.
   ACS Applied Nano Materials, 7, 27016-27023, 2024.
   
8. Akihiro Iyoshi, Atsushi Ueda*, Tomohiro Umeno, Takuma Kato, Kazuhiro Hirayama, Mitsunobu Doi, Masakazu Tanaka*
   Conformational Analysis and Organocatalytic Activity of Helical Stapled Peptides Containing α-Carbocyclic α,α-Disubstituted α-Amino Acids.
   Molecules, 29, 4340, 2024.
   
9. Motoki Naka, Tomohiro Umeno (Co-First), Mika Shibuya, Yuto Yamaberi, Atsushi Ueda, Masakazu Tanaka, Hiroyasu Takemoto, Makoto Oba*
   Intracellular Delivery of Plasmid DNA Using Amphipathic Helical Cell-Penetrating Peptides Containing Dipropylglycine.
   Chemical & Pharmaceutical Bulletin, 72, 512-517, 2024.
   
10. Tomohiro Umeno*, Moeka Fujihara, Shota Matsumoto, Naoko Iizuka, Kazuteru Usui, Satoru Karasawa*
    Quantitative and Nondestructive Colorimetric Amine Detection Method for the Solid-Phase Peptide Synthesis as an Alternative to the Kaiser Test.
    Analytical Chemistry, 95, 15803-15809, 2023.
    
11. Kazuteru Usui*, Ami Amano, Kasumi Murayama, Miho Sasaya, Ryota Kusumoto, Tomohiro Umeno, Satsuki Murase, Naoko Iizuka, Shota Matsumoto, Yasufumi Fuchi, Kazuyuki Takahashi, Masatoshi Kawahata, Yasuhiro Kobori*, Satoru Karasawa*
    Photoisomerization of “Partially Embedded Dihydropyridazine” with a Helical Structure.
    Chemistry-A Europian Journal, 29, e202302413, 2023.
    
12. Tomohiro Umeno*, Lisa Muroi, Yuto Kayama, Kazuteru Usui, Koichi Hamada, Akihiro Mizutani, Satoru Karasawa*
    Naphthyridine-Based Electron Push–Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media.
    Bioconjugate Chemistry, 34, 1439-1446, 2023.
    
13. Kazuteru Usui*, Nozomi Narita, Ryosuke Eto, Seika Suzuki, Atsushi Yokoo, Kosuke Yamamoto, Kazunobu Igawa, Naoko Iizuka, Yuki Mimura, Tomohiro Umeno, Shota Matsumoto, Masashi Hasegawa, Katsuhiko Tomooka, Yoshitane Imai*, Satoru Karasawa*
    Oxidation of an Internal-Edge-Substituted [5]Helicene-Derived Phosphine Synchronously Enhances Circularly Polarized Luminescence.
    Chemistry-A Europian Journal, 28, e2022029, 2022.
    
14. Shota Matsumoto, Tomohiro Umeno, Noriko Suzuki, Kazuteru Usui, Masatoshi Kawahata, Satoru Karasawa*
    Chelate-free “turn-on”-type fluorescence detection of trivalent metal ions.
    Chemical Communications, 58, 12435-12438, 2022.
    
15. Tomohiro Umeno*, Remi Seto, Shota Matsumoto, Moeka Fujihara, Satoru Karasawa*
    Basic Fluorescent Protonation-Type pH Probe Sensitive to Small ΔpKa of Methanol and Ethanol.
    Analytical Chemistry, 94, 10400-10407, 2022.
    
16. Atsushi Ueda*, Yui Makura, Sana Kakazu, Takuma Kato, Tomohiro Umeno, Kazuhiro Hirayama, Mitsunobu Doi, Makoto Oba, Masakazu Tanaka*
    E-Selective Ring-Closing Metathesis in α-Helical Stapled Peptides Using Carbocyclic α,α-Disubstituted α-Amino Acids.
    Organic Letters, 24, 1049-1054, 2022.
    
17. Yuri Fukumoto, Tomohiro Umeno (Co-First), Hina Kuramochi, Koichi Hamada, Shota Matsumoto, Noriko Suzuki, Kazuteru Usui, Akihiro Mizutani, Satoru Karasawa*
    Acid responsiveness of emissive morpholinyl aminoquinolines and their use for cell fluorescence imaging.
    Organic & Biomolecular Chemistry, 20, 4342-4351, 2022.
    
18. Shota Matsumoto, Tomohiro Umeno, Kazuteru Usui, Satoru Karasawa*
    High-Z′ Crystal Structure of Tricyclic Imidazonaphthyridine Derivatives and the Thermal Profiles of Their Polymorphs.
    Crystal Growth & Design, 21, 5251-5260, 2021.
    
19. Yuto Yamaberi, Ryo Eto, Tomohiro Umeno, Takuma Kato, Mitsunobu Doi, Hidetomo Yokoo, Makoto Oba*, Masakazu Tanaka*
    Synthesis of (S)-(−)-Cucurbitine and Conformation of Its Homopeptides.
    Organic Letters, 23, 4358-4362, 2021.
    
20. Kazuki Sato, Tomohiro Umeno, Atsushi Ueda, Takuma Kato, Mitsunobu Doi, Masakazu Tanaka*
    Asymmetric 1,4-Addition Reactions Catalyzed by N-Terminal Thiourea-Modified Helical L-Leu Peptide with Cyclic Amino Acids.
    Chemistry-A Europian Journal, 27, 11216-11220, 2021.
    
21. Tomohiro Umeno*, Kazuteru Usui, Satoru Karasawa*
    π-Extended Push-Pull-Type Bicyclic Fluorophores Based on Quinoline and Naphthyridine Frameworks with an Iminophosphorane Fragment.
    Asian Journal of Organic Chemistry, 10, 1123-1130, 2021.
    
22. Ryusuke Hagihara, Tomohiro Umeno, Shoji Ueki, Daisuke Yoshihara, Yasufumi Fuchi, Kazuteru Usui, Masaomi Sakuma, Ken-ichi Yamada, Satoru Karasawa*
    Push–Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity-Induced Aggregation and Crystallization‐Induced Emission Enhancement and Fluorescence Resonance Energy Transfer.
    Chemistry-A Europian Journal, 27, 3039-3046, 2021.
    
23. Yasufumi Fuchi*, Tomohiro Umeno (Co-First), Yuichiro Abe, Keita Ikeno, Ryu Yamasaki, Iwao Okamoto, Kazuteru Usui*, Satoru Karasawa*
    Characterization of Push–Pull-Type Benzo[X]quinoline Derivatives (X = g or f): Environmentally Responsive Fluorescent Dyes with Multiple Functions.
    The Journal of Organic Chemistry, 85, 13177-13190, 2020.
    
24. Atsushi Ueda*, Mei Higuchi, Kazuki Sato, Tomohiro Umeno, Masakazu Tanaka*
    Design and Synthesis of Helical N-Terminal L-Prolyl Oligopeptides Possessing Hydrocarbon Stapling.
    Molecules, 25, 4667, 2020.
    
25. Hikari Koi, Norihito Takahashi, Yasufumi Fuchi, Tomohiro Umeno, Yukiko Muramatsu, Hiroyuki Seimiya, Satoru Karasawa*, Hiroki Oguri*
    A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.
    Organic & Biomolecular Chemistry, 18, 5339-5343, 2020.
    
26. Keisuke Tsuchiya, Tomohiro Umeno (Co-First), Genichiro Tsuji, Hidetomo Yokoo, Masakazu Tanaka, Kiyoshi Fukuhara, Yosuke Demizu, Takashi Misawa*
    Development of Photoswitchable Estrogen Receptor Ligands.
    Chemical & Pharmaceutical Bulletin, 68, 398-402, 2020.
    
27. Tomohiro Umeno, Atsushi Ueda, Mitsunobu Doi, Takuma Kato, Makoto Oba, Masakazu Tanaka*
    Helical foldamer-catalyzed enantioselective 1,4-addition reaction of dialkyl malonates to cyclic enones.
    Tetrahedron Letters, 60, 151301, 2019.
    
28. Makoto Oba*, Yurika Ito, Tomohiro Umeno, Takuma Kato, Masakazu Tanaka*
    Plasmid DNA Delivery Using Cell-Penetrating Peptide Foldamers Composed of Arg–Arg–Aib Repeating Sequences.
    ACS Biomaterials Science & Engineering, 11, 5660-5668, 2019.
    
29. Atsushi Ueda*, Mei Higuchi, Tomohiro Umeno, and Masakazu Tanaka*
    Enantioselective Synthesis of 2,4,5-Trisubstituted Tetrahydropyrans via Peptide-Catalyzed Michael Addition Followed by Kishi’s Reductive Cyclization.
    HETEROCYCLES, 99, 989-1022, 2019.
    
30. Atsushi Ueda*, Tomohiro Umeno, Mitsunobu Doi, Kengo Akagawa, Kazuaki Kudo, Masakazu Tanaka*
    Helical-Peptide-Catalyzed Enantioselective Michael Addition Reactions and Their Mechanistic Insights.
    The Journal of Organic Chemistry, 81, 6343-6356, 2016.
    
31. Tomohiro Umeno, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Takayuki Hirata, Hiroshi Suemune, Masakazu Tanaka*
    Helical structures of L-Leu-based peptides having chiral six-membered ring amino acids.
    Tetrahedron, 72, 3124-3131, 2016.
    

原著論文（和文）

1. 岸川 直哉, 沼田 翔, 梅野 智大, Mahmoud EL-MAGHRABEY, 大山 要, 田中 正一, 黒田 直敬*
   非天然型アミノ酸を含むペプチドにより修飾したHPLC固定相の調製とその評価
   分析化学, 71, 351-356, 2022.
   

総説（和文）

1. 梅野 智大
   ドナー・アクセプター型分子の特性を利用した分析試薬の開発
   薬学雑誌, 144, 911-918, 2024.
   
2. 松本 祥汰, 梅野 智大, 臼井 一晃, 唐澤 悟*
   プッシュプル型アミノナフチリジン及びアミノキノリン誘導体を基盤とした可逆的酸塩基検出試薬の開発
   分析化学, 71, 119-131, 2021.
   

外部資金

外部資金（代表）

1. 科研費若手研究　2025–27年度
2. 野口遵研究助成金　2025年度
3. 藤森科学技術振興財団研究助成　2024年度
4. 科研費若手研究　2022–24年度
5. 笹川科学研究助成　2022年度
6. 科研費研究活動スタート支援　2020–21年度
7. 特別研究員奨励費　2017–19年度

外部資金（分担）

1. 科研費基盤研究C（代表：唐澤悟）　2022–24年度