京都府立医科大学

医学部医学科 化学教室
大学院医学研究科 医系化学

Graduate School of Medical Science, Kyoto Prefectural University of Medicine

研究業績
accomplishments

原著論文

  1. Hidetomo Yokoo, Norihito Shibata*, Yusuke Demizu*,
    In silico design, synthesis and evaluation of PROTAC against hematopoietic prostaglandin D synthase
    Methods in Molecular Biology, accepted.
  2. Hidetomo Yokoo#, Seiji Tanaka#, Eiichi Yamamoto, Genichiro Tsuji, Yosuke Demizu*, Nahoko Uchiyama*,
    Advanced solid-state NMR analysis of two crystal forms of ranitidine hydrochloride: Detection of 1H-14N intra-/intermolecular correlations.
    Chemical and Pharmaceutical Bulletin, In press
  3. Yuki Murakami#, Hinata Osawa#, Takashi Kurohara#, Yuta Yanase, Takahito Ito, Hidetomo Yokoo, Norihito. Shibata, Mikihiko Naito, Kosuke Aritake, Yosuke Demizu*,
    Structure–Activity Relationship Study of PROTACs against Hematopoietic Prostaglandin D2 Synthase.
    RSC Medicinal Chemistry, 2022, Advance Article
    DOI:10.1039/D2MD00284A
  4. Hidetomo Yokoo#, Takashi Misawa#, Takuma Kato, Masakazu Tanaka, Yosuke Demizu*, Makoto Oba*,
    Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine.
    Bioorganic & Medicinal Chemistry, In press.
    DOI:10.1007/s11095-021-03158-x
  5. Michihiko Aoyama*, Minoru Tada, Hidetomo Yokoo, Yosuke Demizu, Akiko Ishii-Watabe,
    Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates.
    Pharmaceutical Research, 2022, 39, 89-103
    DOI:10.1007/s11095-021-03158-x
  6. Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari, Takahashi, Yuri Takada, Tetsuya, Iida, Makoto Oba, Yukihiko Itoh*, Takayoshi Suzuki*
    Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC).
    Chemical Communications, 2022, 58, 4635-4638
    DOI: 10.1039/D2CC00272H
  7. Atsushi Ueda*, Yui Makura, Sana Kakazu, Takuma Kato, Tomohiro Umeno, Kazuhiro Hirayama, Mitsunobu Doi, Makoto Oba, Masakazu Tanaka*
    E-Selective ring-closing metathesis in α-helical stapled peptides using carbocyclic α,α-disubstituted α-amino acids.
    Organic Letters, 2022, 24, 1049-1054
    DOI: 10.1021/acs.orglett.1c04256
  8. Naoto Yoshinaga, Satoshi Uchida*, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, and Kazunori Kataoka*
    Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelles for efficient mRNA delivery
    Advanced Healthcare Materials, accepted
    DOI: 10.1002/adhm.202102016
  9. Muthuraj Prakash, Yukihiro Itoh*, Yoshie Fujiwara, Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, Takayoshi Suzuki*
    Identification of potent and selective inhibitors of fat mass obesity associated protein using a fragment-merging approach.
    Journal of Medicinal Chemistry, 2021, 64, 15810-15824
    DOI: 10.1021/acs.jmedchem.1c01107
  10. Junjie Li, Zhishen Ge*, Kazuko Toh, Xueying Liu, Anjaneyulu Dirisala, Wendong Ke, Panyue Wen, Hang Zhou, Zheng Wang, Shiyan Xiao, Joachim F. R. Van Guyse, Theofilus A. Tockary, Jinbing Xie, Daniel Gonzalez-Carter, Hiroaki Kinoh, Satoshi Uchida, Yasutaka Anraku, Kazunori Kataoka*
    Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer.
    Advanced Materials, 2021, 2105254
    DOI: 10.1002/adma.202105254
  11. Rimpei Kamegawa, Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, Beob Soo Kim, Kanjiro Miyata*
    Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery.
    ACS Applied Bio Materials, 2021, 4 (11), 7790-7799
    DOI: 10.1021/acsabm.1c00704
  12. Takashi Kurohara, Takahito Ito, Genichiro Tsuji*, Takashi Misawa*, Hidetomo Yokoo, Yuta Yanase, Takuji Shoda, Takatoshi Sakai, Junko Hosoe, Nahoko Uchiyama, Hiroshi Akiyama, Yosuke Demizu
    Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor.
    Bioorganic & Medicinal Chemistry, 2021, 49, 116425
    DOI:10.1016/j.bmc.2021.116425
  13. Hidetomo Yokoo#, Nobumichi Ohoka#, Mami Takyo, Takahito Ito, Keisuke Tsuchiya, Takashi Kurohara, Kiyoshi Fukuhara, Takao Inoue, Mikihiko Naito, Yosuke Demizu*
    Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation.
    International Journal of Molecular Sciences, 2021, 22, 8772
    DOI:10.3390/ijms22168772
  14. Nobumichi Ohoka#, Hidetomo Yokoo#, Keiichiro Okuhira, Yosuke Demizu, Mikihiko Naito*
    Molecular design, synthesis and evaluation of SNIPER(ER) that induces targeted protein degradation of ERα.
    Methods in Molecular Biology, accepted.
  15. Satoshi Uchida*, Yuto Yamaberi, Masakazu Tanaka, Makoto Oba*
    A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA.
    Nanoscale, 2021, 13 (45), 18941-18946
    DOI: 10.1039/D1NR03600A
    Selected as an inside front cover
  16. Takeshi Fuchigami*, Takeshi Chiga, Sakkura Yoshida, Makoto Oba, Yu, Fukushima, Hiromi Inoue, Akari Matsuura, Akira Toriba, Morio Nakayama*
    Synthesis and characterization of radiogallium-labeled cationic amphiphilic peptides as tumor imaging agents.
    Cancers, 2021, 13, 2388
    DOI: 10.3390/cancers13102388
  17. Hidetomo Yokoo*, Motoharu Hirano, Nobumichi Ohoka, Takashi Misawa, Yosuke Demizu*
    Structure-activity relationship study of amphipathic antimicrobial peptides using helix-destabilizing sarcosine.
    Journal of Peptide Science, 2021, e3360
    DOI:10.1002/psc.3360
  18. Hidetomo Yokoo, Norihito Shibata*, Akinori Endo, Takahito Ito, Yuta Yanase, Yuki Murakami, Kiyonaga Fujii, Yasushi Saeki, Mikihiko Naito*, Kosuke Aritake*, Yosuke Demizu*
    Discovery of a highly potent and selective degrader targeting hematopoietic prostaglandin D synthase via in silico design.
    Journal of Medicinal Chemistry, accepted.
    Selected as Supplementary Cover.
    ChemRxiv DOI: 10.26434/chemrxiv.14739486.v1
  19. Hidetomo Yokoo, Eiichi Yamamoto*, Sayaka Masada, Nahoko Uchiyama,Genichiro Tsuji, Takashi Hakamatsuka, Yosuke Demizu, Ken-ichi Izutsu, Yukihiro Goda
    N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride.
    Chemical and Pharmaceutical Bulletin, accepted.
  20. Naoto Yoshinaga, Mitsuru Naito, Yoshihiro Tachihara, Eger Boonstra, Kensuke Osada, Horacio Cabral*, Satoshi Uchida*
    PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials
    Pharmaceutics, 2021, 13, 800
    DOI: 10.3390/pharmaceutics13060800
  21. Yuto Yamaberi, Ryo Eto, Tomohiro Umeno, Takuma Kato, Mitsunobu Doi, Hidetomo Yokoo, Makoto Oba*, Masakazu Tanaka*
    Synthesis of (S)-(–)-cucurbitine and conformation of its homopeptides.
    Organic Letters, 2021, 23, 4358-4362
    DOI:10.1021/acs.orglett.1c01291
    Selected as a supplementary cover.
  22. Hanqiao Xu, Nobumichi Ohoka, Hidetomo Yokoo, Kanako Nemoto, Takashi Ohtsuki, Hiroshi Matsufuji, Mikihiko Naito, Takao Inoue, Genichiro Tsuji*, Yousuke Demizu*
    Development of agonist-based PROTACs targeting liver X receptor.
    Frontiers in Chemistry, 2021, 9, 674967
    DOI:10.3389/fchem.2021.674967
  23. Yoshinori Tsukumo, Genichiro Tsuji, Hidetomo Yokoo, Norihito Shibata, Nobumichi Ohoka, Yusuke Demizu, Mikihiko Naito*
    Protocols for synthesis of SNIPERs and the methods to evaluate the anticancer effects.
    Methods in Molecular Biology, 2021, 2365, 331-347
  24. Eger Boonstra, Hiroaki Hatano, Yuji Miyahara, Satoshi Uchida*, Tatsuro Goda*, Horacio Cabral*
    A proton/macromolecule-sensing approach distinguishes changes in biological membrane permeability during polymer/lipid-based nucleic acid delivery
    Journal of Materials Chemistry B, 2021, 9, 4298-4302
    DOI: 10.1039/D1TB00645B
  25. Takuma Kato*, Yuki Kita, Kazuki Iwanari, Akiko Asano, Makoto Oba, Masakazu Tanaka, Mitsunobu Doi
    Synthesis of six-membered carbocyclic ring α,α-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide.
    Bioorganic & Medicinal Chemistry, 2021, 38, 116111
    DOI: 10.1016/j.bmc.2021.116111
  26. Saed Abbasi, Satoshi Uchida*, Kazuko Toh, Theofilus A. Tockary, Anjaneyulu Dirisala, Kotaro Hayashi, Shigeto Fukushima, Kazunori Kataoka*
    Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain.
    Journal of Controlled Release, 2021, 332, 260–268
    DOI: 10.1016/j.jconrel.2021.02.026
  27. Tetsuya Iida, Yukihiro Itoh*, Yukari Takahashi, Yasunobu Yamashita, Takashi Kurohara, Yuka Miyake, Makoto Oba, Takayoshi Suzuki*
    Design, synthesis, and biological evaluation of lysine demethylase 5C degraders
    ChemMedChem, 2021, 16, 1609–1618
    DOI: 10.1002/cmdc.202000933
    Selected as a front cover.
    Selected as a very important paper.
  28. Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka*
    Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle
    Biomaterials, 2021, 270, 120681
    DOI: 10.1016/j.biomaterials.2021.120681
  29. Naoto Yoshinaga, Satoshi Uchida*, Anjaneyulu Dirisala, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka*
    mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency
    Journal of Controlled Release, 2021, 330, 317-328
    DOI: 10.1016/j.jconrel.2020.12.033
  30. Takuya Miyazaki, Satoshi Uchida, Hiroaki Hatano, Yuji Miyahara, Akira Matsumoto, Horacio Cabral*
    Guanidine-phosphate interactions stabilize polyion complex micelles based on flexible catiomers to improve mRNA delivery
    European Polymer Journal, 2020, 140, 10882-10886
    DOI: 10.1016/j.eurpolymj.2020.110028
  31. Atsushi Ueda, Misuzu Ikeda, Takuya Kasae, Mitsunobu Doi, Yosuke Demizu, Makoto Oba, Masakazu Tanaka*
    Synthesis of chiral α-trifluoromethyl α,α-disubstituted α-amino acids and conformational analysis of L-Leu based peptides with (R)- or (S)-α-trifluoromethylanaline
    ChemistrySelect, 2020, 5, 10882-10886
    DOI: 10.1002/slct.202002888
  32. Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Takuya Miyazaki, Kazunori Kataoka, Kensuke Osada, Horacio Cabral*, Satoshi Uchida*
    Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo
    Biomaterials, 2020, 261, 120332
    DOI: 10.1016/j.biomaterials.2020.120332
  33. Takuya Miyazaki, Satoshi Uchida, Satoru Nagatoishi, Kyoko Koji, Taehun Hong, Shigeto Fukushima, Kouhei Tsumoto, Kazuhiko Ishihara, Kazunori Kataoka, Horacio Cabral*
    Polymeric nanocarriers with controlled chain flexibility boost mRNA delivery in vivo through enhanced structural fastening
    Advanced Healthcare Materials, 2020, 9(16) , e2000538
    DOI: 10.1002/adhm.202000538
    Selected as an inside back cover.
  34. Anjaneyulu Dirisala, Satoshi Uchida*, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka*
    Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines
    Science Advances, 2020, 6(26), eabb8133
    DOI: 10.1126/sciadv.abb8133
  35. Satoshi Uchida*, Kayoko Yanagihara, Akitsugu Matsui, Kazunori Kataoka, Keiji Itaka*
    mRNA as a tool for gene transfection in 3D cell culture for future regenerative therapy
    Micromachines, 2020, 11(4), 426
    DOI: 10.3390/mi11040426
  36. Ryosuke Ueki*, Satoshi Uchida, Naoto Kanda, Naoki Yamada, Ayaka Ueki, Momoko Akiyama, Kazuko Toh, Horacio Cabral, Shinsuke Sando*
    A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application
    Science Advances, 2020, 6(14), eaay2801
    DOI: 10.1126/sciadv.aay2801
  37. Kaori Furukawa, Masakazu Tanaka, Makoto Oba*
    siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells
    Bioorganic & Medicinal Chemistry, 2020, 28(8), 115402.
    DOI: 10.1016/j.bmc.2020.115402
  38.  

総説(英文)

  1. Hidetomo Yokoo*, Miyako Naganuma, Makoto Oba, Yosuke Demizu*,
    Recent Advances in PROTAC Technology toward New Therapeutic Modalities.
    Chemistry & Biodiversity, 2022 e202200828
    DOI: 10.1002/cbdv.2022008288
  2. Hidetomo Yokoo, Makoto Oba*, Satoshi Uchida*
    Cell-penetrating peptides: emerging tools for mRNA delivery.
    Pharmaceutics, 2022, 14(1), 78
    DOI: 10.3390/pharmaceutics14010078
  3. Saed Abbasi*, Satoshi Uchida*
    Multifunctional immunoadjuvants for use in minimalist nucleic acid vaccines
    Pharmaceutics, 2021, 13, 644
    DOI: doi:10.3390/pharmaceutics13050644
  4. Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral*
    Nanomedicine-based approaches for mRNA delivery
    Molecular Pharmaceutics, 2020, 17(10), 3654-3684
    DOI: 10.1021/acs.molpharmaceut.0c00618
    Selected as a cover page

総説(和文)

  1. 大庭 誠
    非天然型の側鎖構造を有するアミノ酸の設計・合成と機能性ペプチドへの応用
    有機合成化学協会誌, 2022, 80(1) 36-45
    DOI: 10.5059/yukigoseikyokaishi.80.36
  2. 大庭 誠
    ペプチドフォルダマーの特性と機能
    ファルマシア, 2021, 57(9), 828-831
  3. 内田 智士
    mRNAワクチンの基盤技術とCOVID-19への展開
    臨床とウイルス, 2021, 49(3), 133-138
  4. 内田 智士
    RNAオリゴマーを用いたmRNA修飾法の開発とmRNA送達, ワクチンへの展開
    核酸医薬学会会誌2021, 2021, 16-26
  5. 内田 智士
    メッセンジャーRNAのワクチン及び医薬品としての応用
    京都府立医科大学雑誌, 2021, 30(7),441-449
  6. 内田 智士
    細胞編集のツールとしてのmRNA―生存促進mRNAを用いた疾患治療と細胞移植
    Yakugaku Zasshi, 2021, 141 655-659
    DOI: 10.1248/yakushi.20-00219-5
  7. 大庭 誠
    中分子ペプチド創薬
    京都府立医科大学雑誌, 2020, 129(11) 747-753
    DOI: 10.32206/jkpum.129.11.747
  8. 内田 智士,位高 啓史
    相補鎖RNAオリゴマーを用いたmRNA修飾と,そのmRNA送達,ワクチンへの応用
    バイオマテリアル ―生体材料―, 2020, 38(2) 106-111

国際会議論文

  1. Satoshi Uchida*, Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Horacio Cabral
    mRNA Structuring for Stabilizing mRNA Nanocarriers and Improving Their Delivery Efficiency
    Materials Proceedings, 2021,4, 82.
    DOI: 10.3390/IOCN2020-07789
  2. Satoshi Uchida, Kyoko Koji, Naoto Yoshinaga, Horacio Cabral
    Assembling several mRNA strands for facilitating mRNA delivery with and without using carriers
    Molecular Therapy, 2021, 29 (4, S1), 55.
  3. Eger Boonstra, Hiroaki Hatano, Tatsuro Goda, Satoshi Uchida, Horacio Cabral, Yuji Miyahara
    Mechanistic Analyses of Polymer/Lipid-Based Gene Transfection Processes through Membrane Integrity Assay Using Proton Sensing Transistor
    Materials Proceedings, 2021, 4, 53.
    DOI: 10.3390/IOCN2020-07988
  4. Takuya Miyazaki, Satoshi Uchida, Yuji Miyahara, Akira Matsumoto, Horacio Cabral
    Development of Flexible Polycation-Based mRNA Delivery Systems for In Vivo Applications
    Materials Proceedings, 2021,4, 5.
    DOI: 10.3390/IOCN2020-07857

著書

  1. Tomoya Hirano, Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika, Development of Novel Fluorescent Sensors Based on Fluorescent Natural Compounds Biomedical Engineering, Jenny Stanford Publishing, Chapter6 (2021)
  2. 内田智士, アジュバント機能一体型部分2本鎖mRNAを用いたワクチン, 創薬研究者がこれだけは知っておきたい最新のウイルス学 510-518
  3. 内田 智士,ワクチンの効きが悪い条件を逆手にとった自己免疫疾患の治療薬の開発,実験医学 2021年5月号 Vol.39 No.8 CRISPR最新ツールボックス 1237-1238
  4. 内田 智士,核酸が切り開くCOVID-19ワクチン開発 実験医学2020年8月号 Vol.38 No.13 RAN翻訳と相分離で紐解くリピート病 2206-2207

招待・依頼講演

  1. 大庭 誠,中分子ペプチドを用いたDDS技術, 日本薬学会第142年会 一般シンポジウム「中分子創薬研究のフロンティア〜ニューモダリティへの戦略展開〜」,オンライン,2022年3月28日
  2. 大庭 誠,中分子医薬品(核酸医薬品・ペプチド医薬品)におけるDDS技術と製剤化,中分子・高分子医薬品におけるDDS技術と実用化 サイエンス&テクノロジー株式会社主催セミナー,オンライン,2022年3月23日
  3. 内田 智士,RNA architectonicsを基盤としたmRNA送達とワクチン,日本バイオマテリアル学会関西ブロック 第16回若手研究発表会,関西大学,2021年12月4日,基調講演
  4. 内田 智士,SDGsとバイオマテリアル,第43回日本バイオマテリアル学会大会,名古屋国際会議場,2021年11月28日,教育講演
  5. 内田 智士,COVID-19 mRNAワクチンの科学応用物理学会,有機分子・バイオエレクトロニクス分科会,第12回市民講座「コロナウイルスとたたかう応用物理 -2年目の技術の最前線-」,オンライン,2021年11月6日
  6. 内田 智士,mRNA医薬を用いた疾患治療について,Pharma R&D Conference 2021,オンライン,2021年10月28日
  7. 大庭 誠,細胞内へのmRNAの送達を可能にする化学修飾技術の開発と製剤化, mRNA医薬品のDDS技術開発と製剤化 技術情報協会主催セミナー,オンライン,2021年10月8日
  8. 内田 智士,mRNA医薬品の今後の投与経路考察と研究開発動向, mRNA医薬品のDDS技術開発と製剤化 技術情報協会主催セミナー,オンライン,2021年10月8日
  9. 内田 智士,新型コロナウイルス感染症に対する救世主〜かわさき発のワクチンを目指してmRNAワクチン,2021年度後期かわさき市民アカデミー・地域協働講座(企業連携講座)「地域社会に貢献している川崎の会社と人々 その22,川崎市生涯学習プラザ(神奈川県川崎市) , 2021年10月7日
  10. 内田 智士,メッセンジャーRNAワクチン~新型コロナウイルスからがん治療へ,第38回日本癌学会市民公開講座 先端技術と社会背景により変わるがん医療, パシフィコ横浜(神奈川県横浜市), 2021年10月2日
  11. 内田 智士,2本鎖PEG-オリゴリシンを用いた肝類洞壁一過的コーティングによるナノ医薬品の体内動態制御,第70回高分子討論会,オンライン,2021年9月7日
  12. 内田 智士,COVID-19に対するmRNAワクチン開発の動向と独自の取り組み,JAACT2021日本動物細胞工学会,オンライン,2021年7月28日
  13. 内田 智士,mRNA医薬、遺伝子治療薬の全身投与に向けた取り組み,日本核酸医薬学会第6回年会,オンライン,2021年6月28日
  14. 内田 智士,,新型コロナウイルスワクチンについて,京都府立医科大学附属北部医療センター,第1回府民公開講座,京都府丹後文化会館,2021年6月27日
  15. 大庭 誠,mRNA医薬の細胞への効率的送達を目指した化学修飾技術・DDS技術,mRNA医薬品の研究開発動向と開発戦略 技術情報協会主催セミナー,オンライン,2021年5月27日
  16. 内田 智士,新型コロナウイルスとmRNAワクチン – mRNA医薬のワクチンへの応用とその先, EWE三月会 – 早稲田電気工学会,オンライン,2021年5月17日
  17. 内田 智士,mRNAワクチンとその先のmRNA医薬の展望, 京都大学同窓会ヘルスケアネットワーク令和,オンライン,2021年5月15日
  18. 内田 智士,新型コロナワクチン開発の動向と背景,公益財団法人大隅基礎科学創成財団 第5回アドバイザー会議,オンライン,2021年4月23日
  19. 内田 智士,ところで、ワクチンってどうナノ?,第1回iCONM市民公開講座,「ナノ医療って何ナノ??」,オンライン,2021年3月27日
  20. 内田 智士,万能薬にもなるメッセンジャーRNAの謎に迫る!〜コロナウイルスに対する救世主,サイエンスカフェ@ふくおか,オンライン,2021年3月5日
  21. 内田 智士,メッセンジャーRNA医薬のCOVID-19ワクチンへの応用とその先,日本学術振興,先端ナノデバイス・材料テクノロジー第151委員,オンライン,2021年3月5日
  22. 内田 智士,メッセンジャーRNAのCOVID-19ワクチンへの応用とその後の展望,一般社団法人 医療産業イノベーション機構主催,2020年度 医療産業イノベーションフォーラム,オンライン,2021年2月25日
  23. 内田 智士,メッセンジャーRNAを用いたCOVID-19ワクチン開発とその先へ,東京大学大学院工学系研究科バイオエンジニアリング専攻主催、次世代医療技術研究会、令和2年度第5回情報交換会,オンライン,2021年2月24日
  24. 内田 智士,新型コロナウイルスや未来のパンデミックに対するmRNAナノワクチンの開発,第7回COINSシンポジウム ~小さく寄り添い大きく守る、未来の医療はすぐそこに~(オンライン,2020年12月4日)
  25. Satoshi Uchida, mRNA nanomachine for treating rare genetic disorders, India-Japan Webinar on "Rare Genetic Disorders”, organized by Embassy of India, Tokyo (Online, Oct. 16, 2020)
  26. 内田 智士, RNA構造に着目したメッセンジャーRNA 医薬の機能化, 第69回 高分子討論会(オンライン, 2020年9月18日)
  27. 大庭 誠, 核酸・遺伝子をデリバリーする膜透過性ペプチドに関する研究, 第69回 高分子討論会(オンライン, 2020年9月18日)
  28. 内田 智士, DNA、mRNAのex vivo導入による細胞治療の効果向上, 第36回日本DDS学会学術集会(神戸, 2020年8月29日)
  29. 内田 智士, 細胞編集のツールとしてのmRNA –生存促進mRNAを用いた疾患治療と細胞移植, 日本薬学会第140年会(京都, 2020年3月26日)

外部資金

  1. 日本医療研究開発機構 (AMED): 革新的先端研究開発支援事業(インキュベートタイプ:LEAP) 内田・分担(代表: 名古屋大学 阿部 洋 教授) 2021–25年度
  2. 国立研究開発法人科学技術振興機構 共創の場形成支援プログラム 大庭・分担(代表: 京都大学 沼田 圭司 教授) 2021–22年度
  3. 科学研究費 挑戦的研究(萌芽) 内田・代表 2021–22年度
  4. 科学研究費 基盤研究 (A) 内田・代表 2021–24年度
  5. 日本医療研究開発機構 (AMED): 新興・再興感染症に対する革新的医薬品等開発推進研究事業 内田・代表 2021–23年度
  6. 篷庵社 特別研究助成 大庭・代表 2021-22年度
  7. テルモ生命科学振興財団 研究助成 大庭・代表 2020-21年度
  8. 日本医療研究開発機構 (AMED): 中分子医薬品等の新規ドラッグデリバリーシステムの開発 内田・分担(研究代表:名大、木村 康明) 2020–22年度
  9. 科学研究費 基盤研究 (B) 内田・分担(研究代表:東大、Horacio Cabral) 2020–22年度
  10. 京都ヘルスサイエンス総合研究センター共同研究 大庭・分担(研究代表:京都薬大、古田 巧) 2020年度
  11. 旭硝子財団 研究奨励(自然科学系) 大庭・代表 2019-20年度
  12. 日本医療研究開発機構 (AMED): 再生医療・遺伝子治療の産業化に向けた基盤技術開発事業 (遺伝子治療製造技術開発) 内田・代表 2018–20年度
  13. 科学研究費 基盤研究 (B) 内田・代表 2018–20年度

受賞

  1. ENT M Dr.浅野登&暉子基金医学基礎研究助成(2021年11月)
    横尾 英知
  2. 日本核酸医薬学会 奨励賞(DDS) (2020年11月)
    タイトル: RNAオリゴマーを用いたmRNA修飾法の開発とmRNA送達、ワクチンへの展開
    内田 智士
  3. 8th International mRNA Health Conference, 1st Abstract Prize (2020年11月)
    タイトル: mRNA bundling inside polyion complexes for their physical and biological stabilization.
    著者: Satoshi Uchida, Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Horacio Cabral.

原著論文

  1. Tomohiro Umeno, Atsushi Ueda, Mitsunobu Doi, Takuma Kato, Makoto Oba, Masakazu Tanaka*
    Helical foldamer-catalyzed enantioselective 1,4-addition reaction of dialkyl malonates to cyclic enones
    Tetrahedron Letters, 2019, 60(49), 151301.
    DOI: 10.1016/j.tetlet.2019.151301
  2. Takashi Misawa†*, Nobumichi Ohoka†*, Makoto Oba, Hiroko Yamashita, Masakazu Tanaka, Mikihiko Naito, Yosuke Demizu* (†: equal contribution)
    Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers (CPFs) for efficient siRNA delivery
    Chemical Communications, 2019, 55, 7792-7795.
    DOI: 10.1039/C9CC02203A
  3. Makoto Oba*, Yurika Ito, Tomohiro Umeno, Takuma Kato, Masakazu Tanaka
    Plasmid DNA delivery using cell-penetrating peptide foldamers composed of Arg-Arg-Aib repeating sequences
    ACS Biomaterials Science & Engineering, 2019, 5, 5660-5668.
    DOI: 10.1021/acsbiomaterials.8b01451
  4. Makoto Oba*, Yu Nagano, Takuma Kato, Masakazu Tanaka
    Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers
    Scientific Reports, 2019, 9, 1349.
    DOI: 10.1038/s41598-018-38063-8
  5. Yurie Koba, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Takuma Kato, Yosuke Demizu, Masakazu Tanaka*
    Left-handed helix of three-membered ring amino acid homopeptide interrupted by an N–H···ethereal O type hydrogen bond
    Organic Letters, 2018, 20(24), 7830-7834.
    DOI: 10.1021/acs.orglett.8b03331
  6. Masakazu Tanaka*, Haruka Yakabi, Haruki Nakatani, Atsushi Ueda, Mitsunobu Doi, Makoto Oba
    Helical structures of cyclopentene-based α,α-disubstituted α-amino acid homopeptides
    Chimia, 2018, 72(12), 848-852.
    DOI: 10.2533/chimia.2018.848
  7. Takuma Kato, Makoto Oba*, Koyo Nishida, Masakazu Tanaka*
    Cell-penetrating peptides using cyclic α,α-disubstituted α-amino acids with basic functional groups
    ACS Biomaterials Science & Engineering, 2018, 4(4), 1368-1376.
    DOI: 10.1021/acsbiomaterials.8b00180
  8. Hiroyuki Kobayashi, Takashi Misawa*, Makoto Oba, Naoya Hirata, Yasunari Kanda, Masakazu Tanaka, Kenji Matsuno, Yosuke Demizu*
    Structural development of cell-penetrating peptides containing cationic proline derivatives
    Chemical & Pharmaceutical Bulletin, 2018, 66(5), 575-580.
    DOI: 10.1248/cpb.c18-00079
    Highlight paper selected by Editor-in Chief.
  9. Makoto Oba*, Chika Ito, Masakazu Tanaka
    Effects of five-membered ring amino acid incorporation into peptides for coiled coil formation
    Bioorganic & Medicinal Chemistry Letters, 2018, 28(5), 875-877.
    DOI: 10.1016/j.bmcl.2018.02.002
  10. Ryo Eto, Makoto Oba, Atsushi Ueda, Tsubasa Uku, Mitsunobu Doi, Yosuke Matsuo, Takashi Tanaka, Yosuke Demizu, Masaaki Kurihara, Masakazu Tanaka*
    Diastereomeric right- and left-handed helical structures with fourteen (R)-chiral centers
    Chemistry A European Journal, 2017, 23(72), 18120-18124.
    DOI: 10.1002/chem.201705306
    Selected as a frontispiece.
  11. Yurie Koba, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masakazu Tanaka*
    Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety
    ChemistrySelect, 2017, 2, 8108-8114.
    DOI: 10.1002/slct.201700832
  12. Kaori Furukawa, Makoto Oba*, Kotomi Toyama, George Ouma Opiyo, Yosuke Demizu, Masaaki Kurihara, Mitsunobu Doi, Masakazu Tanaka*
    Low pH-triggering changes in peptide secondary structures
    Organic & Biomolecular Chemistry, 2017, 15(30), 6302-81146305.
    DOI: 10.1039/C7OB01374D
    Selected as a cover picture.
  13. Makoto Oba*, Masayuki Kunitake, Takuma Kato, Atsushi Ueda, Masakazu Tanaka*
    Enhanced and prolonged cell-penetrating abilities of arginine-rich peptides by introducing cyclic α,α-disubstituted α-amino acids with stapling
    Bioconjugate Chemistry, 2017, 28(7), 1801-1806.
    DOI: 10.1021/acs.bioconjchem.7b00190
  14. Hiroko Yamashita, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Masaaki Kurihara*, Yosuke Demizu*
    Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters
    Bioorganic & Medicinal Chemistry, 2017, 25(6), 1846-1851.
    DOI: 10.1016/j.bmc.2017.01.044
  15. Qixian Chen, Kensuke Osada*, Zhishen Ge, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Akitsugu Matsui, Kazuko Toh, Kaori M. Takeda, Xueying Liu, Takahiro Nomoto, Takehiko Ishii, Makoto Oba, Yu Matsumoto, Kazunori Kataoka*
    Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting
    Biomaterials, 2017, 113, 253-265.
    DOI: 10.1016/j.biomaterials.2016.10.042
  16. Yosuke Demizu*, Koyo Okitsu, Mitsunobu Doi, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara*
    Influence of L-Leu to D-Leu replacement on the helical secondary structures of L-Leu-Aib based dodecapeptides
    ChemistrySelect, 2016, 1, 5805-5811.
    DOI: 10.1002/slct.201601493
  17. Hiroko Yamashita, Takuma Kato, Makoto Oba, Takashi Misawa, Takayuki Hattori, Nobumichi Ohoka, Masakazu Tanaka, Mikihiko Naito, Masaaki Kurihara*, Yosuke Demizu*
    Development of a cell-penetrating peptide that exhibits responsive changes in its secondary structure in the cellular environment
    Scientific Reports, 2016, 6, 33003.
    DOI: 10.1038/srep33003
  18. Atsushi Ueda, Makoto Oba, Yuki Izumi, Yasuhiro Sueyoshi, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masakazu Tanaka*
    Helical structures of homo-chiral isotope-labeled α-aminoisobutyric acid peptides
    Tetrahedron, 2016, 72(39), 5864-5871.
    DOI: 10.1016/j.tet.2016.08.011
  19. Yosuke Demizu*, Mitsunobu Doi, Hiroko Yamashita, Takashi Misawa, Makoto Oba, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka
    The side-chain hydroxy groups of a cyclic α,α-disubstituted α-amino acid promote oligopeptide 310-helix packing in the crystalline state
    Biopolymers (Peptide Science), 2016, 106(5), 757-768.
    DOI: 10.1002/bip.22881
  20. Yurie Koba, Yoko Hirata, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masakazu Tanaka*
    Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformation of its homo-chiral homopeptides
    Biopolymers (Peptide Science), 2016, 106(4), 555-562.
    DOI: 10.1002/bip.22769
  21. Takuma Kato†, Hiroko Yamashita†, Takashi Misawa, Koyo Nishida, Masaaki Kurihara, Masakazu Tanaka, Yosuke Demizu*, Makoto Oba* (†: equal contribution)
    Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids
    Bioorganic & Medicinal Chemistry, 2016, 24(12), 2681-2687.
    DOI: 10.1016/j.bmc.2016.04.031
  22. Kaori Furukawa, Makoto Oba*, George Ouma Opiyo, Mitsunobu Doi, Masakazu Tanaka*
    Cyclic α,α-disubstituted α-amino acids with menthone in their side chains through an acetal moiety and helical structures of their peptides
    European Journal of Organic Chemistry, 2016, 17, 2988-2998.
    DOI: 10.1002/ejoc.201600241
  23. Tomohiro Umeno, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Takayuki Hirata, Hiroshi Suemune, Masakazu Tanaka*
    Helical structures of L-Leu-based peptides having chiral six-membered ring amino acids
    Tetrahedron, 2016, 72(22), 3124-3131.
    DOI: 10.1016/j.tet.2016.04.040
  24. Yosuke Demizu*, Koyo Okitsu, Hiroko Yamashita, Mitsunobu Doi, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara*
    α-Helical structures of oligopeptides with alternating L-Leu-Aib segment
    European Journal of Organic Chemistry, 2016, 16, 2815-2820.
    DOI: 10.1002/ejoc.201600327
  25. Hirokuni Uchida, Keiji Itaka, Satoshi Uchida, Takehiko Ishii, Tomoya Suma, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka*
    Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure
    Journal of the American Chemical Society, 2016, 138(15), 1478-1481.
    DOI: 10.1021/jacs.5b11726
  26. Makoto Oba*, Hikaru Nonaka, Mitsunobu Doi, Masakazu Tanaka*
    Conformational studies on peptides having dipropylglycine (Dpg) or 1-aminocycloheptanecarboxylic acid (Ac7c) within the sequence of L-leucine (Leu) residues
    Biopolymers (Peptide Science), 2016, 106(2), 210-218.
    DOI: 10.1002/bip.22810
  27. Makoto Oba*, Takuma Kato, Kaori Furukawa, Masakazu Tanaka
    A cell-penetrating peptide with a guanidinylethyl amine structure directed to gene delivery
    Scientific Reports, 2016, 6, 19913.
    DOI: 10.1038/srep19913
  28. Yosuke Demizu*, Hiroko Yamashita, Takashi Misawa, Mitsunobu Doi, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara*
    Handedness preference of heterochiral helical peptides by attaching a homochiral peptide segment
    European Journal of Organic Chemistry, 2016, 4, 840-846.
    DOI: 10.1002/ejoc.201501146
  29. Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara*, Yosuke Demizu*
    A helix-stabilized cell-penetrating peptide as an intracellular delivery tool
    ChemBioChem, 2016, 17(2), 137-140.
    DOI: 10.1002/cbic.201500468
    Selected as a cover picture.
  30. Yosuke Demizu*, Hiroko Yamashita, Mitsunobu Doi, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara*
    Topological study of the structures of heterochiral peptides containing equal amounts of L-Leu and D-Leu
    The Journal of Organic Chemistry, 2015, 80(17), 8597-8603.
    DOI: 10.1021/acs.joc.5b01541
  31. Makoto Oba*, Yosuke Demizu, Hiroko Yamashita, Masaaki Kurihara, Masakazu Tanaka
    Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides
    Bioorganic & Medicinal Chemistry, 2015, 23(15), 4911-4918.
    DOI: 10.1016/j.bmc.2015.05.025
  32. Yosuke Demizu*, Makoto Oba, Kouyo Okitsu, Hiroko Yamashita, Takashi Misawa, Masakazu Tanaka, Masaaki Kurihara, Samuel H. Gellman
    A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides
    Organic & Biomolecular Chemistry, 2015, 13(20), 5617-5620.
    DOI: 10.1039/C5OB00389J
  33. Kazuhiro Tanda, Ryo Eto, Kazuya Kato, Makoto Oba, Atsushi Ueda, Hiroshi Suemune, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masakazu Tanaka*
    Peptide foldamers composed of six-membered ring α,α-disubstituted α-amino acids with two changeable chiral acetal moieties
    Tetrahedron, 2015, 71(23), 3909-3914.
    DOI: 10.1016/j.tet.2015.04.031
  34. Takayuki Hirata, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masanobu Nagano, Hiroshi Suemune, Masakazu Tanaka*
    Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and α-helices
    Tetrahedron, 2015, 71(16), 2409-2420.
    DOI: 10.1016/j.tet.2015.02.075
  35. Makoto Oba*, Naomi Kawabe, Hiroomi Takazaki, Yosuke Demizu, Mitsunobu Doi, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka*
    Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues
    Tetrahedron, 2014, 70(46), 8900-8907.
    DOI: 10.1016/j.tet.2014.09.086
  36. Takuma Kato, Makoto Oba*, Koyo Nishida, Masakazu Tanaka
    Cell-penetrating helical peptides having L-arginines and five-membered ring α,α-disubstituted α-amino acids
    Bioconjugate Chemistry, 2014, 25(10), 1761-1768.
    DOI: 10.1021/bc5003949
  37. Makoto Oba, Hiroomi Takazaki, Naomi Kawabe, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Hiromu Kawakubo, Masanobu Nagano, Hiroshi Suemune, Masakazu Tanaka*
    Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups
    The Journal of Organic Chemistry, 2014, 79(19), 9125-9140.
    DOI: 10.1021/jo501493x
  38. Hirokuni Uchida, Keiji Itaka, Takahiro Nomoto, Takehiko Ishii, Tomoya Suma, Masaru Ikegami, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka*
    Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection
    Journal of the American Chemical Society, 2014, 136(35), 12396-12405.
    DOI: 10.1021/ja506194z
    Selected as Spotlight of JACS.
  39. Anjaneyulu Dirisala, Kensuke Osada*, Qixian Chen, Theofilus A. Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka*
    Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors
    Biomaterials, 2014, 35(20), 5359-5368.
    DOI: 10.1016/j.biomaterials.2014.03.037
  40. Hiroko Yamashita, Yosuke Demizu*, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara*
    Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability
    Bioorganic & Medicinal Chemistry, 2014, 22(8), 2403-2408.
    DOI: 10.1016/j.bmc.2014.03.005
  41. Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kaori Machitani, Arnida, Yu Matsumoto, Makoto Oba, Kanjiro Miyata, Kensuke Osada, Nobuhiro Nishiyama*, Kazunori Kataoka*
    Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer
    Nature Communications, 2014, 5, 3545.
    DOI: 10.1038/ncomms4545
  42. Zhishen Ge, Qixian Chen, Kensuke Osada*, Xueying Liu, Theofilus A. Tockary, Satoshi Uchida, Anjaneyulu Dirisala, Takehiko Ishii, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Makoto Oba, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka*
    Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors
    Biomaterials, 2014, 35(10), 3416-3426.
    DOI: 10.1016/j.biomaterials.2013.12.086
  43. Takuma Kato, Masakazu Tanaka, Makoto Oba*
    Protein transfection study using multicellular spheroids of human hepatoma Huh-7 cells
    PLoS ONE, 2013, 8(12), e82876.
    DOI: 10.1371/journal.pone.0082876
  44. Makoto Oba*, Naoko Ishikawa, Yosuke Demizu, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka*
    Helical oligomer with changeable chiral acetal moiety
    European Journal of Organic Chemistry, 2013, 34, 7679-7682.
    DOI: 10.1002/ejoc.201301450
  45. Makoto Oba*, Atsushi Shimabukuro, Miyako Ono, Mitsunobu Doi, Masakazu Tanaka*
    Synthesis of both enantiomers of cyclic methionine analogue: (R)- and (S)-3-aminotetrahydrothiophene-3-carboxylic acids
    Tetrahedron: Asymmetry, 2013, 24(8), 464-467.
    DOI: 10.1016/j.tetasy.2013.03.010
  46. Kosuke Anan, Yosuke Demizu, Makoto Oba, Masaaki Kurihara, Mitsunobu Doi, Hiroshi Suemune, Masakazu Tanaka*
    Helical structures of bicyclic α-amino acid homo-chiral oligomers with the stereogenic centers at the side-chain fused-ring junctions
    Helvetica Chimica Acta, 2012, 95(10), 1694-1713.
    DOI: 10.1002/hlca.201200403
  47. Makoto Oba*, Masakazu Tanaka
    Intracellular internalization mechanism of protein transfection reagents
    Biological & Pharmaceutical Bulletin, 2012, 35(7), 1064-1068.
    DOI: 10.1248/bpb.b12-00001
  48. Qixian Chen, Kensuke Osada*, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A. Tockary, Taisuke Endo, Zhishen Ge, Hiroaki Kinoh, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka*
    Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors
    Biomaterials, 2012, 33(18), 4722-4730.
    DOI: 10.1016/j.biomaterials.2012.03.017
  49. Hyun Jin Kim, Makoto Oba, Frederico Pittella, Takahiro Nomoto, Horacio Cabral, Yu Matsumoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka*
    PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor
    Journal of Drug Targeting, 2012, 20(1), 33-42.
    DOI: 10.3109/1061186X.2011.632010
  50. Hideo Kagaya, Makoto Oba, Yutaka Miura, Hiroyuki Koyama*, Takehiko Ishii, Takae Shimada, Tsuyoshi Takato, Kazunori Kataoka, Tetsuro Miyata
    Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions
    Gene Therapy, 2012, 19(1), 61-69.
    DOI: 10.1038/gt.2011.74
  51. Aya Iriyama*, Makoto Oba, Takehiko Ishii, Nobuhiro Nishiyama, Kazunori Kataoka, Yasuhiro Tamaki, Yasuo Yanagi
    Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo
    PLoS ONE, 2011, 6(12), e28560.
    DOI: 10.1371/journal.pone.0028560
  52. Aya Iriyama*, Tomohiko Usui, Yasuo Yanagi, Shiro Amano, Makoto Oba, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
    Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo
    Cornea, 2011, 30(12), 1423-1427.
    DOI: 10.1097/ICO.0b013e318206c893
  53. Hirokuni Uchida, Kanjiro Miyata, Makoto Oba, Takehiko Ishii, Tomoya Suma, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka*
    Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles
    Journal of the American Chemical Society, 2011, 133(39), 15524-15532.
    DOI: 10.1021/ja204466y
  54. Frauke M. König, Yelena Vachutinsky, Makoto Oba, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Christoph Bräuchle, Nadia Ruthardt*
    Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging
    Journal of Controlled Release, 2011, 156(3), 364-373.
    DOI: 10.1016/j.jconrel.2011.08.003
  55. Stephanie Herlambang, Michiaki Kumagai, Takahiro Nomoto, Souta Horie, Shigeto Fukushima, Makoto Oba, Kozo Miyazaki, Yuji Morimoto, Nobuhiro Nishiyama*, Kazunori Kataoka*
    Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy
    Journal of Controlled Release, 2011, 155(3), 449-457.
    DOI: 10.1016/j.jconrel.2011.06.019
  56. Yasutaka Anraku, Akihiro Kishimura*, Atsushi Kobayashi, Makoto Oba, Kazunori Kataoka*
    Size-controlled long-circulating PICsome as ruler to measure critical cut-off disposition size into normal and tumor tissues
    Chemical Communications, 2011, 47(21), 6054-6056.
    DOI: 10.1039/C1CC11465D
  57. Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Nobuhiro Nishiyama, Tatsuya Yamasoba, Kazunori Kataoka*
    In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy
    Journal of Controlled Release, 2011, 151(2), 104-109.
    DOI: 10.1016/j.jconrel.2011.02.011
    Selected as a cover picture.
  58. Yelena Vachutinsky, Makoto Oba, Kanjiro Miyata, Shigehiro Hiki, Mitsunobu R. Kano, Nobuhiro Nishiyama, Hiroyuki Koyama, Kohei Miyazono, Kazunori Kataoka*
    Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles
    Journal of Controlled Release, 2011, 149(1), 51-57.
    DOI: 10.1016/j.jconrel.2010.02.002
    Selected as a cover picture.
  59. Makoto Oba, Kanjiro Miyata, Kensuke Osada, R. James Christie, Mai Sanjoh, Weidong Li, Shigeto Fukushima, Takehiko Ishii, Mitsunobu R. Kano, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka*
    Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery
    Biomaterials, 2011, 32(2), 652-663.
    DOI: 10.1016/j.biomaterials.2010.09.022
  60. Yu Matsumoto, Takahiro Nomoto, Horacio Cabral, Yoko Matusmoto, Sumiyo Watanabe, R. James Christie, Kanjiro Miyata, Makoto Oba, Tadayoshi Ogura, Yuichi Yamasaki, Nobuhiro Nishiyama, Tatsuya Yamasoba, Kazunori Kataoka*
    Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography
    Biomedical Optics Express, 2010, 1(4), 1209-1216.
    DOI: 10.1364/BOE.1.001209
  61. Hiroyasu Takemoto, Atsushi Ishii, Kanjiro Miyata, Masataka Nakanishi, Makoto Oba, Takehiko Ishii, Yuichi Yamasaki, Nobuhiro Nishiyama, Kazunori Kataoka*
    Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system
    Biomaterials, 2010, 31(31), 8097-8105.
    DOI: 10.1016/j.biomaterials.2010.07.015
    Selected as ‘The new Biomaterials Year in Images poster-2010 edition’.
  62. Hyun Jin Kim, Atsushi Ishii, Kanjiro Miyata, Yan Lee, Shourong Wu, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka*
    Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown
    Journal of Controlled Release, 2010, 145(2), 141-148.
    DOI: 10.1016/j.jconrel.2010.03.019
  63. Mai Sanjoh, Shigehiro Hiki, Yan Lee, Makoto Oba, Kanjiro Miyata, Takehiko Ishii, Kazunori Kataoka*
    pDNA/poly(L-lysine) polyplexes functionalized with a pH-sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells
    Macromolecular Rapid Communications, 2010, 31(13), 1181-1186.
    DOI: 10.1002/marc.201000056
    Selected as a cover picture.
  64. Makoto Oba, Yelena Vachutinsky, Kanjiro Miyata, Mitsunobu R. Kano, Sorato Ikeda, Nobuhiro Nishiyama*, Keiji Itaka, Kohei Miyazono, Hiroyuki Koyama, Kazunori Kataoka*
    Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1
    Molecular Pharmaceutics, 2010, 7(2), 501-509.
    DOI: 10.1021/mp9002317
  65. Kanjiro Miyata, Noha Gouda, Hiroyasu Takemoto, Makoto Oba, Yan Lee, Hiroyuki Koyama, Yuichi Yamasaki, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka*
    Enhanced transfection with silica-coated polyplexes loading plasmid DNA
    Biomaterials, 2010, 31(17), 4764-4770.
    DOI: 10.1016/j.biomaterials.2010.02.033
  66. Yasutaka Anraku, Akihiro Kishimura*, Makoto Oba, Yuichi Yamasaki, Kazunori Kataoka*
    Spontaneous formation of nano-sized uni-lamellar polyion complex vesicles (nano-PICsomes) with tunable size and properties
    Journal of the American Chemical Society, 2010, 132(5), 1631-1636.
    DOI: 10.1021/ja908350e
  67. Hideki Shimizu, Yuichi Hori, Shinya Kaname, Koei Yamada, Nobuhiro Nishiyama, Satoru Matsumoto, Kanjiro Miyata, Makoto Oba, Akira Yamada, Kazunori Kataoka, Toshiro Fujita*
    siRNA-based therapy for glomerulonephritis
    Journal of the American Society of Nephrology, 2010, 21(4), 622-633.
    DOI: 10.1681/ASN.2009030295
  68. Makoto Oba, Yosuke Demizu*, Nanako Yamagata, Yukiko Sato, Mitsunobu Doi, Masakazu Tanaka, Hiroshi Suemune, Haruhiro Okuda, Masaaki Kurihara*
    Solid-state conformation of diastereomeric -Pro-Pro-(Aib)4 sequences
    Tetrahedron, 2010, 66(13), 2293-2296.
    DOI: 10.1016/j.tet.2010.02.003
  69. Muri Han, Makoto Oba, Nobuhiro Nishiyama, Mitsunobu R. Kano, Shinae Kizaka-Kondoh, Kazunori Kataoka*
    Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles
    Molecular Therapy, 2009, 17(8), 1404-1410.
    DOI: 10.1038/mt.2009.119
  70. Satoru Matsumoto, R. James Christie, Nobuhiro Nishiyama, Kanjiro Miyata, Atsushi Ishii, Makoto Oba, Hiroyuki Koyama, Yuichi Yamasaki, Kazunori Kataoka*
    Environmental-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery
    Biomacromolecules, 2009, 10(1), 119-127.
    DOI: 10.1021/bm800985e
  71. Kanjiro Miyata, Makoto Oba, Masataka Nakanishi, Shigeto Fukushima, Yuichi Yamasaki, Hiroyuki Koyama, Nobuhiro Nishiyama, Kazunori Kataoka*
    Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity
    Journal of the American Chemical Society, 2008, 130(48), 16287-16294.
    DOI: 10.1021/ja804561g
  72. Makoto Oba, Kazuhiro Aoyagi, Kanjiro Miyata, Yu Matsumoto, Keiji Itaka, Nobuhiro Nishiyama, Yuichi Yamasaki, Hiroyuki Koyama, Kazunori Kataoka*
    Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking
    Molecular Pharmaceutics, 2008, 5(6), 1080-1092.
    DOI: 10.1021/mp800070s
  73. Kanjiro Miyata, Makoto Oba, Mitsunobu R. Kano, Shigeto Fukushima, Yelena Vachutinsky, Muri Han, Hiroyuki Koyama, Kohei Miyazono, Nobuhiro Nishiyama, Kazunori Kataoka*
    Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue
    Pharmaceutical Research, 2008, 25(12), 2924-2936.
    DOI: 10.1007/s11095-008-9720-2
    Selected as a cover picture.
  74. Yuko Fujihara, Hiroyuki Koyama*, Makoto Ohba, Yasuhiko Tabata, Hisako Fujihara, Yoshiyuki Yonehara, Tsuyoshi Takato
    Controlled delivery of bFGF to recipient bed enhances the vascularization and viability of an ischemic skin flap
    Wound Repair and Regeneration, 2008, 16(1), 125-131.
    DOI: 10.1111/j.1524-475X.2007.00339
  75. Yan Lee, Kanjiro Miyata, Makoto Oba, Takehiko Ishii, Shigeto Fukushima, Muri Han, Hiroyuki Koyama, Nobuhiro Nishiyama, Kazunori Kataoka*
    Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery
    Angewandte Chemie International Edition, 2008, 47(28), 5163-5166.
    DOI: 10.1002/anie.200800963
  76. Seiji Takae, Kanjiro Miyata, Makoto Oba, Takehiko Ishii, Nobuhiro Nishiyama, Keiji Itaka, Yuichi Yamasaki, Hiroyuki Koyama, Kazunori Kataoka*
    PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors
    Journal of the American Chemical Society, 2008, 130(18), 6001-6009.
    DOI: 10.1021/ja800336v
  77. Yoshihiro Yasuda, Hiroyuki Koyama*, Yasuhiko Tabata, Yuko Fujihara, Makoto Oba, Eiju Uchimura, Tsuyoshi Takato
    Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle
    Journal of Surgical Research, 2008, 147(1), 132-137.
    DOI: 10.1016/j.jss.2007.10.009
  78. Masataka Nakanishi, Joon-Sik Park, Woo-Dong Jang, Makoto Oba, Kazunori Kataoka*
    Study of quantitative aminolysis reaction of poly(β-benzyl L-aspartate) (PBLA) as a platform polymer for functionality materials
    Reactive & Functional Polymers, 2007, 67(11), 1361-1372.
    DOI: 10.1016/j.reactfunctpolym.2007.08.009
  79. Makoto Oba, Shigeto Fukushima, Naoki Kanayama, Kazuhiro Aoyagi, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka*
    Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing αvβ3 and αvβ5 integrins
    Bioconjugate Chemistry, 2007, 18(5), 1415-1423.
    DOI: 10.1021/bc0700133
  80. Muri Han, Younsoo Bae, Nobuhiro Nishiyama, Kanjiro Miyata, Makoto Oba, Kazunori Kataoka*
    Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiency
    Journal of Controlled Release, 2007, 121(1-2), 38-48.
    DOI: 10.1016/j.jconrel.2007.05.012
  81. Daisuke Akagi, Makoto Oba, Hiroyuki Koyama, Nobuhiro Nishiyama, Shigeto Fukushima, Tetsuro Miyata, Hirokazu Nagawa, Kazunori Kataoka*
    Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation
    Gene Therapy, 2007, 14(13), 1029-1038.
    DOI: 10.1038/sj.gt.3302945
  82. Makoto Oba, Masakazu Tanaka*, Yukiko Takano, Hiroshi Suemune*
    Concise synthesis strategy toward cyclic α,α-disubstituted α-amino acids bearing delta-nitrogen atom: chiral 1-substituted 4-aminopiperidine-4-carboxylic acids
    Tetrahedron, 2005, 61(3), 593-598.
    DOI: 10.1016/j.tet.2004.11.004
  83. Masakazu Tanaka*, Shin Nishimura, Makoto Oba, Yosuke Demizu, Masaaki Kurihara, Hiroshi Suemune*
    An extended planar C5 conformation and 310-helical structure of peptide foldamer consisted of diverse α-ethylated α,α-disubstituted α-amino acids
    Chemistry, A European Journal, 2003, 9(13), 3082-3090.
    DOI: 10.1002/chem.200204476
  84. Makoto Oba, Masakazu Tanaka*, Masaaki Kurihara, Hiroshi Suemune*
    Conformation of peptides containing a chiral α-ethylated α,α-disubstituted α-amino acid: (S)-α-ethylleucine (= (2S)-2-amino-2-ethyl-4-methylpentanoic acid) within sequence of dimethylglycine and diethylglycine residues
    Helvetica Chimica Acta, 2002, 85(10), 3197-3218.
    DOI: 10.1002/1522-2675(200210)85:10<3197::AID-HLCA3197>3.0.CO;2-Y
  85. Masakazu Tanaka*, Makoto Oba, Koichi Tamai, Hiroshi Suemune*
    Asymmetric synthesis of α,α-disubstituted α-amino acids using (S,S)-cyclohexane-1,2-diol as chiral auxiliary
    The Journal of Organic Chemistry, 2001, 66(8), 2667-2673.
    DOI: 10.1021/jo001423m
  86. Masakazu Tanaka*, Makoto Oba, Naoto Imawaka, Masaaki Kurihara, Hiroshi Suemune*
    Conformational study of heteropentapeptides containing an α-ethylated α,α-disubstituted amino acid: (S)-butylethylglycine (= 2-amino-2-ethylhexanoic acid) within a sequence of dimethylglycine (2-aminoisobutyric acid) residues
    Helvetica Chimica Acta, 2001, 84(1), 32-46.
    DOI: 10.1002/1522-2675(20010131)84:1<32::AID-HLCA32>3.0.CO;2-4
  87. Masakazu Tanaka*, Makoto Oba, Takaharu Ichiki, Hiroshi Suemune*
    Solid-state conformation of hybrid tripeptide between β-amino acid: 8-aminocyclooct-4-enecarboxylic acid and 2-aminoisobutyric acid
    Chemical & Pharmaceutical Bulletin, 2001, 49(9), 1178-1181.
    DOI: 10.1248/cpb.49.1178

総説

  1. Makoto Oba*
    Cell-penetrating peptide foldamers: Drug delivery tools
    ChemBioChem, 2019, 20(16), 2041-2045.
    DOI: 10.1002/cbic.201900204
  2. 大庭 誠*
    ペプチドフォルダマーの構造制御と膜透過機能
    Yakugaku Zasshi, 2019, 139(4), 599-608.
    DOI: 10.1248/yakushi.18-00179-3
  3. 大庭 誠*, 梅澤直樹, 出水庸介
    フォルダマーの魅力—設計・構造・機能—
    Yakugaku Zasshi, 2019, 139(4), 579-580.
    DOI: 10.1248/yakushi.18-00179-F
  4. Makoto Oba*
    Study on development of polymeric micellar gene carrier and evaluation of its functionality
    Biological & Pharmaceutical Bulletin, 2013, 36(7), 1045-1051.
    DOI: 10.1248/bpb.b13-00287
  5. 野本貴大, 松本 有, 藤 加珠子, R. James Christie, 宮田完二郎, 大庭 誠, Horacio Cabral, 村上真美, 福島重人, 西山伸宏, 片岡一則*
    リアルタイム生体内共焦点レーザー顕微鏡を用いたdrug delivery system (DDS)の動態評価法
    Yakugaku Zasshi, 2012, 132(12), 1347-1354.
    DOI: 10.1248/yakushi.12-00234-1
  6. 小山博之, 大庭 誠, 片岡一則
    ナノミセルの血管外科領域への応用
    Surgery Frontier, 2010, 17(2), 44-48.
  7. 大庭 誠, 小山博之, 片岡一則
    血管壁への遺伝子デリバリーを目的とした非ウイルスベクターの開発
    Angiology Frontier, 2009, 8(3), 56-61.
  8. 大庭 誠, 片岡一則
    高分子ミセル型DDS
    ファルマシア, 2009, 45(3), 227-231.
  9. 大庭 誠, 片岡一則
    ナノバイオテクノロジーとドラッグデリバリーシステム
    脈管学, 2009, 48, 371-377.
  10. 田中正一, 大庭 誠
    ピペリジン骨格を有する非天然型アミノ酸の合成法
    ファインケミカル, 2008, 37(3), 42-48.
  11. 大庭 誠, 片岡一則
    ナノテクノロジー
    脈管学, 2006, 46, 727-733.
  12. 大庭 誠, 片岡一則
    産業の観点から見た安全安心の実用化ナノDDS
    分子血管病, 2006, 7(4), 382-387.
  13. 大庭 誠, 小山博之, 片岡一則
    血管疾患遺伝子治療用高分子ミセル型ナノ構造体
    再生医療, 2006, 5(1), 78-83.

国際会議論文

  1. Hiroyuki Kobayashi, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Kenji Matsuno, Yosuke Demizu, Development of cationic cell-penetrating peptides focused on their secondary structures, Peptide Science 2017, 2018, 98-99.
  2. Atsushi Ueda, Takuya Kasae, Makoto Oba, Mitsunobu Doi, Masakazu Tanaka, Synthesis of enantiomerically pure α-amino acids and conformational studies of their L-leucine-based peptides, Abstracts of Papers, 254th ACS National Meeting & Exposition, 2017, ORGN-119.
  3. Takashi Misawa, Yosuke Demizu, Hiroko Yamashita, Takuma Kato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara, Development of helix-stabilized amphiphatic cell-penetrating peptide using helical promoter, Peptide Science 2016, 2017, 11-12.
  4. Yu Fukushima, Takeshi Fuchigami, Hiromi Inoue, Natsumi Ishikawa, Sakura Yoshida, Makoto Oba, Morio Nakayama, Evaluation of cationic amphiphilic peptides as potential probes for cancer imaging, Peptide Science 2016, 2017, 117-118.
  5. Hiroko Yamashita, Yosuke Demizu, Takashi Misawa, Takayuki Hattori, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Masaaki Kurihara, Development of helix-stabilized cationic peptides with cell-membrane penetrating ability, Peptide Science 2015, 2016, 29-30.
  6. Yurie Koba, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masakazu Tanaka, Conformational analysis of peptides composed of chiral cyclic amino acids, Peptide Science 2015, 2016, 145-146.
  7. Hiroko Yamashita, Yosuke Demizu, Takashi Misawa, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara, Development of stabilized short helical peptides with cell-membrane penetrating ability, Peptide Science 2014, 2015, 149-150.
  8. Ryo Eto, Makoto Oba, Atsushi Ueda, Naoko Ishikawa, Masaaki Kurihara, Yosuke Demizu, Hiroshi Suemune, Mitsunobu Doi, Masakazu Tanaka, Synthesis and conformational analysis of helical oligomers with a changeable chiral acetal moiety, Peptide Science 2014, 2015217-218.
  9. Yosuke Demizu, Hiroko Yamashita, Yukiko Sato, Mitsunobu Doi, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara, Helical screw-sense control of LD-peptides containing equal amounts of L- and D-amino acids, Peptide Science 2013, 2014, 271-272.
  10. Ai Imanishi, Makoto Oba, Yosuke Demizu, Masaaki Kurihara, Mitsunobu Takazaki, Hiroshi Suemune, Masakazu Tanaka, Synthesis of chiral five-membered ring amino acids with an azido group, and their peptides, Peptide Science 2012, 2013, 131-132.
  11. Ikumi Kato, Makoto Oba, Masaaki Kurihara, Yukiko Takano, Masakazu Tanaka, Synthesis of cyclic α,α-disubstituted amino acids bearing a pendent chiral center, Peptide Science 2012, 2013, 129-130.
  12. Tomomi Hanada, Takuma Kato, Emi Ikeda, Yosuke Demizu, Masaaki Kurihara, Mitsunobu Doi, Yuko Tsuda, Makoto Fukudome, Makoto Oba, Masakazu Tanaka, Design and synthesis of conformational freedom restricted endomorphin-2 analogues, Peptide Science 2011, 2012, 103-104.
  13. Yoko Hirata, Makoto Oba, Makoto Fukudome, Yosuke Demizu, Masaaki Kurihara, Mitsunobu Doi, Masakazu Tanaka, Synthesis and conformational analysis of peptides composed of chiral five-membered ring amino acids, Peptide Science 2011, 2012, 101-102.
  14. Kanjiro Miyata, Takahiro Nomoto, Hiroyasu Takemoto, Hyun Jin Kim, Yu Matsumoto, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka, Development of advanced polymer-based nanodevices for nucleic acids delivery, Abstracts of Papers, 240th ACS National Meeting, 2010, PMSE-178.
  15. Nanako Yamagata, Yosuke Demizu, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Mitsunobu Doi, Kazuo Nagasawa, Hiroshi Suemune, Haruhiro Okuda, Masaaki Kurihara, Controlling the helical screw sense of peptide by N-terminal proline, Peptide Science 2009, 2010, 383-384.
  16. Daisuke Akagi, Makoto Oba, Hiroyuki Koyama, Nobuhiro Nishiyama, Shigeto Fukushima, Tetsuro Miyata, Hirokazu Nagawa, Kazunori Kataoka, Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation, Journal of Gene Medicine, 2008, 10(4), 474.
  17. Hiroshi Suemune, Makoto Oba, Yukiko Takano, Masakazu Tanaka, Design and synthesis of cyclic α,α-disubstituted α-amino acids: 1-substituted 4-aminopiperidine-4-carboxylic acids, Peptides 2004, 2005, 275-276.
  18. Masaaki Kurihara, Haruhiko Okuda, Makoto Oba, Yosuke Demizu, Masakazu Tanaka, Hiroshi Suemune, Prediction of helical screw sense of oligopeptides containing chiral α,α-disubstituted α-amino acids: computational study, Peptides 2004, 2005, 1027-1028.
  19. Masakazu Tanaka, Yosuke Demizu, Kosuke Anan, Naomi Kawabe, Yukiko Takano, Makoto Oba, Tokumi Maruyama, Mitsunobu Doi, Hiroshi Suemune, Relationship between α-amino acid chiral center and helical secondary structure of its oligopeptides, Peptide Science 2004, 2005, 45-46.
  20. Masaaki Kurihara, Yukiko Sato, Wataru Hakamata, Haruhiko Okuda, Yosuke Demizu, Kosuke Anan, Yukiko Takano, Makoto Oba, Mitsunobu Doi, Masakazu Tanaka, Hiroshi Suemune, Computational study on conformation of oligopeptides controlled by side chain chiralities of α-amino acids, Peptide Science 2004, 2005, 297-298.
  21. Yukiko Takano, Makoto Oba, Masakazu Tanaka, Hiroshi Suemune, Synthesis of cyclic α,α-disubstituted amino acids bearing a delta-nitrogen atom, Peptide Science 2003, 2004, 137-138.
  22. Makoto Oba, Masakazu Tanaka, Hiroshi Suemune, Yukiko Sato, Masaaki Kurihara, Controlling the secondary structure of Aib peptides by N-terminal proline, Peptide Science 2003, 2004, 397-398.
  23. Masaaki Kurihara, Yukiko Sato, Satoshi Nomoto, Haruhiko Okuda, Makoto Oba, Yosuke Demizu, Masakazu Tanaka, Hiroshi Suemune, Prediction of screw sense of oligopeptides containing chiral amino acids: computational study, Peptide Science 2003, 2004, 411-412.
  24. Makoto Oba, Masakazu Tanaka, Masaaki Kurihara, Hiroshi Suemune, Conformational study of peptides containing (S)-ethylleucine as a chiral α,α-disubstituted amino acid, Peptides 2002, 2003, 242-243.
  25. Masaaki Kurihara, Masakazu Tanaka, Makoto Oba, Hiroshi Suemune, Computational study on conformation of oligopeptides containing chiral α,α-disubstituted amino acids, Peptides 2002, 2003, 786-787.
  26. Masakazu Tanaka, Shin Nishimura, Makoto Oba, Yosuke Demizu, Masaaki Kurihara, Hiroshi Suemune, Conformational study of heteropeptide prepared from chiral α-ethylated α,α-disubstituted α-amino acids, Peptides 2002, 2003, 902-903.
  27. Masaaki Kurihara, Yukiko Sato, Akari Matsuzaki, Masakazu Tanaka, Makoto Oba, Yosuke Demizu, Hiroshi Suemune, Haruhiro Okuda, Prediction of helical screw sense of oligopeptides containing chiral α,α-disubstituted amino acids, Peptide Science 2002, 2003, 323-324.
  28. Masakazu Tanaka, Makoto Oba, Masaaki Kurihara, Yosuke Demizu, Shin Nishimura, Kazuhiro Hayashida, Hiroshi Suemune, Asymmetric synthesis and conformational analysis of α,α-disubstituted α-amino acids and their peptides, Peptide Science 2001, 2002, 263-266.
  29. Masaaki Kurihara, Masakazu Tanaka, Makoto Oba, Hiroshi Suemune, Naoki Miyata, Conformation of oligopeptides containing chiral α,α-disubstituted amino acids: computational study, Peptide Science 2001, 2002, 287-288.
  30. Masakazu Tanaka, Naoto Imawaka, Makoto Oba, Masaaki Kurihara, Hiroshi Suemune, Conformational study of peptides containing α-ethylated α,α-disubstituted amino acid, Peptides 2000, 2001, 441-442.
  31. Masaaki Kurihara, Masakazu Tanaka, Makoto Oba, Hiroshi Suemune, Naoki Miyata, Computational study on conformation of oligopeptides prepared from α,α-disubstituted amino acids, Peptides 2000, 2001, 427-428.

著書

  1. 大庭 誠, 田中正一, ペプチドの体内安定化技術の開発の現状と今後の動向, 医薬品モダリティの特許戦略と技術開発動向, 技術情報協会, 東京, 2019, 226-234.
  2. 大庭 誠, 田中正一, ジ置換アミノ酸を利用した膜透過性ペプチドの開発, ペプチド医薬品のスクリーニング・安定化・製剤化技術, 技術情報協会, 東京, 2017, 307-315.
  3. 大庭 誠, 田中正一, α,α−ジ置換アミノ酸の設計・合成とそのペプチドの二次構造解析・機能化, 遺伝子医学MOOK 21 最新ペプチド合成技術とその創薬研究への応用, 木曽良明 編, メディカル ドゥ 大阪, 2012, 21, 205-210.
  4. 大庭 誠, 片岡一則, 遺伝子キャリアとしての高分子ミセル, 遺伝子医学MOOK 5 先端生物医学研究・医療のための遺伝子導入テクノロジー ウイルスを用いない遺伝子導入方法の材料, 技術, 方法論の新たな展開, 田畑泰彦, 原島秀吉 編, メディカル ドゥ 大阪, 2006, 5, 56-61.

招待・依頼講演

  1. 大庭 誠, 非天然型アミノ酸の設計・合成とその含有ペプチドの二次構造ならびに膜透過機能に関する研究, 有機合成化学協会九州山口支部2019年度第2回有機合成化学講演会, 有機合成化学協会九州山口支部奨励賞受賞講演(水俣, 2019年10月23日).
  2. Makoto Oba, Development of cell-penetrating peptide foldamers as drug delivery tools, The 5th Japan-Taiwan Joint Symposium for Pharmaceutical Sciences (Taipei City, August 30th, 2019)
  3. Makoto Oba, Structure and function of peptide foldamers containing unnatural amino acids, Biomacromolecular RIKEN Seminar (Wako, January 23rd, 2019)
  4. Makoto Oba, Masakazu Tanaka, Cell-penetrating peptide foldamers for drug delivery system, 10th International Peptide Symposium (Kyoto, December 6th, 2018)
  5. 大庭 誠, 細胞膜透過性ペプチドの生体内安定化技術, 細胞膜透過性ペプチドの探索, 応用, 生体内安定化技術 技術情報協会主催セミナー(東京, 2018年10月12日)
  6. 大庭 誠, ペプチドフォルダマーの構造制御と膜透過機能, 日本薬学会第138年会 一般シンポジウム「フォルダマーの魅力—設計・構造・機能—」(金沢, 2018年3月26日)
  7. 大庭 誠, フランス・ボルドー留学〜仕事と私事〜, 第2回長崎大学薬学部グローバル人材育成講演会(長崎, 2018年1月26日)
  8. 大庭 誠, 高分子ミセル型遺伝子キャリアの開発およびその機能評価に関する研究, 日本薬学会第133年会, 薬学会奨励賞受賞講演(横浜, 2013年3月29日)
  9. Makoto Oba, Anti-angiogenic pancreatic cancer gene therapy using polyplex micelle, CMSI Students Seminar (Tokyo, May 1st, 2009)
  10. Makoto Oba, Polyplex micelle for plasmid DNA delivery, Workshop in Jilin University (Changchun, April 9th, 2009)
  11. Makoto Oba, Anti-angiogenic gene therapy for pancreatic cancer by systemic administration of polyplex micelles, GCOE student’s workshop: Polyplex systems for gene and siRNA delivery (Tokyo, November 19th, 2008)
  12. 大庭 誠, 高分子ミセル型ドラッグデリバリーシステムとその血管疾患への応用, 第26回再生医療カンファレンス(東京, 2008年7月3日)

外部資金

  1. 小柳財団 研究助成 大庭・代表 2018年度
  2. テルモ生命科学芸術財団 大庭・代表 2017-18年度
  3. 持田記念医学薬学振興財団 研究助成 大庭・代表 2017-18年度
  4. 住友財団 基礎科学研究助成 大庭・代表 2016-17年度
  5. 武田科学振興財団 薬学研究奨励 大庭・代表 2016-19年度
  6. 科学研究費 国際共同研究加速気金(国際共同研究強化(B)) 大庭・代表 2015-17年度
  7. 科学研究費 基盤研究(C) 大庭・分担(研究代表:長崎大、淵上剛志) 2015-17年度
  8. 倉田記念日立科学技術財団 倉田奨励金 大庭・代表 2014-15年度
  9. 科学研究費 若手研究(A) 大庭・代表 2013-16年度
  10. 科学研究費 挑戦的萌芽研究 大庭・代表 2013-15年度
  11. 持田記念医学薬学振興財団 研究助成 大庭・代表 2012-13年度
  12. 武田科学振興財団 薬学研究奨励 大庭・代表 2012-14年度
  13. テルモ科学技術振興財団 一般研究助成 大庭・代表 2011年度
  14. 科学研究費 若手研究(A) 大庭・代表 2008-11年度
  15. 科学研究費 挑戦的萌芽研究 大庭・代表 2008-09年度
  16. 科学研究費 基盤研究(B) 大庭・分担(研究代表:東京大、米原啓之→小山博之) 2007-09年度
  17. 科学研究費 基盤研究(B) 大庭・分担(研究代表:東京大、宮田哲郎) 2005-07年度
  18. 特別研究員奨励費 大庭・代表 2002-03年度